Hemodynamic impingement and the initiation of intracranial side-wall aneurysms

Riccardello, Gerald J; Changa, Abhinav R; Al‐Mufti, Fawaz; Singh, Inder Paul; Gandhi, Chirag D.; Roman, Max; Prestigiacomo, Charles J.

doi:10.1177/1591019918754380

Cited by 6 publications

(3 citation statements)

References 21 publications

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“…197 Blood flow in IA exhibits several fluid dynamics phenomena depending on the morphology of parent and daughter arteries, as well as the size and location of the IA. Shear layers, 198 precessing vortices, 199,200 jet impingement, 201,202 recirculation and separation zones 203,204 are inherently found in IAs. IA hemodynamics, therefore, are quite different from pulsatile pipe flows investigated in literature for turbulence transition criteria.…”

Section: Resultsmentioning

confidence: 99%

What does computational fluid dynamics tell us about intracranial aneurysms? A meta-analysis and critical review

Saqr

Rashad

Tupin

et al. 2019

J Cereb Blood Flow Metab

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Despite the plethora of published studies on intracranial aneurysms (IAs) hemodynamic using computational fluid dynamics (CFD), limited progress has been made towards understanding the complex physics and biology underlying IA pathophysiology. Guided by 1733 published papers, we review and discuss the contemporary IA hemodynamics paradigm established through two decades of IA CFD simulations. We have traced the historical origins of simplified CFD models which impede the progress of comprehending IA pathology. We also delve into the debate concerning the Newtonian fluid assumption used to represent blood flow computationally. We evidently demonstrate that the Newtonian assumption, used in almost 90% of studies, might be insufficient to describe IA hemodynamics. In addition, some fundamental properties of the Navier–Stokes equation are revisited in supplementary material to highlight some widely spread misconceptions regarding wall shear stress (WSS) and its derivatives. Conclusively, our study draws a roadmap for next-generation IA CFD models to help researchers investigate the pathophysiology of IAs.

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Section: Resultsmentioning

confidence: 99%

What does computational fluid dynamics tell us about intracranial aneurysms? A meta-analysis and critical review

Saqr

Rashad

Tupin

et al. 2019

J Cereb Blood Flow Metab

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“…32 Riccardello et al also concluded that secondary flow patterns may play a major role in the initiation of side-wall aneurysm initiation. 33…”

Section: Reason For Observation Of High Wssd and High Plc In Bifurcation And Sidewall De Novo Casesmentioning

confidence: 99%

Computational fluid dynamic analysis of the initiation of cerebral aneurysms

Fujimura

Tanaka²,

Takao

et al. 2022

Journal of Neurosurgery

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OBJECTIVE Relationships between aneurysm initiation and hemodynamic factors remain unclear since de novo aneurysms are rarely observed. Most previous computational fluid dynamics (CFD) studies have used artificially reproduced vessel geometries before aneurysm initiation for analysis. In this study, the authors investigated the hemodynamic factors related to aneurysm initiation by using angiographic images in patients with cerebral aneurysms taken before and after an aneurysm formation. METHODS The authors identified 10 cases of de novo aneurysms in patients who underwent follow-up examinations for existing cerebral aneurysms located at a different vessel. The authors then reconstructed the vessel geometry from the images that were taken before aneurysm initiation. In addition, 34 arterial locations without aneurysms were selected as control cases. Hemodynamic parameters acting on the arterial walls were calculated by CFD analysis. RESULTS In all de novo cases, the aneurysmal initiation area corresponded to the highest wall shear stress divergence (WSSD point), which indicated that there was a strong tensile force on the arterial wall at the initiation area. The other previously reported parameters did not show such correlations. Additionally, the pressure loss coefficient (PLc) was statistically significantly higher in the de novo cases (p < 0.01). The blood flow impact on the bifurcation apex, or the secondary flow accompanied by vortices, resulted in high tensile forces and high total pressure loss acting on the vessel wall. CONCLUSIONS Aneurysm initiation may be more likely in an area where both tensile forces acting on the vessel wall and total pressure loss are large.

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“…[18][19][20][21][22] More recently, location-based hemodynamic and computed fluid dynamic models have been conducted to understand the appearance and evolution of IA and have demonstrated different patterns of WSS in the cerebral arterial tree. [23][24][25][26] Considering the importance of WSS sensing in aneurysmal disease, we hypothesized that IAs distribution and the diameter of affected arteries could differ between ADPKD and non-ADPKD patients. To investigate differences between demographic data of ADPKD and non-ADPKD patients and differences between characteristics of their IAs, we analyzed combined data from six studies from the literature and three independent cohorts.…”

Section: Introductionmentioning

confidence: 99%