Hemodynamic efficacy of E-1020 in comparison with dopamine on acute mitral regurgitation in anesthetized dogs.

Tanio, Hitoshi; Kumada, Toshiaki; Hayashi, Masataka; Himura, Yoshihiro; Nakamura, Yasuyuki; Kawai, Chuichi

doi:10.1253/jcj.55.1068

Cited by 12 publications

(1 citation statement)

References 25 publications

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“…Cardiac output was calculated by Doppler echocardiographic measurement as left ventricular outflow area x time velocity integral of ejection flow x heart rate, and systemic vascular resistance was calculated as mean blood pressure/cardiac output. We found that olprinone significantly increased cardiac output and decreased systemic vascular resistance (Table 1) (38); this finding suggested both, positive inotropic and vasodilator actions (30,31,44). In a placebo-controlled double-blind study involving patients with acute heart failure olprinone (10 ìg/kg + 0.3 ìg/kg/min) produced a 50% decrease in pulmonary wedge pressure and a ca.…”

Section: Effects On Cardiac Functionmentioning

confidence: 58%

Olprinone: A Phosphodiesterase III Inhibitor with Positive Inotropic and Vasodilator Effects

Mizushige

Ueda

Yukiiri

et al. 2002

Cardiovascular Drug Reviews

262

105

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Olprinone is a newly developed phosphodiesterase III inhibitor characterized by several properties. First, olprinone has positive inotropic and vasodilator actions and improves myocardial mechanical efficiency. Second, olprinone augments cerebral blood flow by a direct vasodilatory effect on cerebral arteries. The cerebrovascular reactivity to olprinone is marked in patients with impaired cerebral circulation. Third, olprinone selectively improves carotid artery distensibility, which may be attributable to differences in the arterial structural components or the reactivity of smooth muscle cells to olprinone. Fourth, olprinone improves inadequate redistribution of brain perfusion and may prevent cerebral metabolic abnormalities in heart failure.

show abstract

Section: Effects On Cardiac Functionmentioning

confidence: 58%

Olprinone: A Phosphodiesterase III Inhibitor with Positive Inotropic and Vasodilator Effects

Mizushige

Ueda

Yukiiri

et al. 2002

Cardiovascular Drug Reviews

262

105

View full text Add to dashboard Cite

show abstract

E-1020, a water soluble imidazopyridine, has direct effects on Ca2+-dependent force and ATP hydrolysis of canine and bovine cardiac myofilaments

Powers¹,

Palmiter²,

Solaro³

1996

Biochemical Mechanisms in Heart Function

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E-1020, a water soluble imidazopyridine, has direct effects on Ca2+-dependent force and ATP hydrolysis of canine and bovine cardiac myofilaments

1996

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E-1020 is a cardiotonic agent that acts as a cyclic-AMP phosphodiesterase inhibitor but also may have actions which alter myofilament response to Ca2+. To identify direct actions of E-1020 on cardiac contractile proteins, effects of E-1020 on myofibrillar Ca2+ dependent MgATPase and force generation in chemically skinned fiber bundles were measured. In bovine cardiac myofibrils, E-1020 (100 microM) significantly increased myofilament Ca2+ sensitivity and Ca(2+)-dependent ATPase activity at submaximal pCa values. At pCa 6.75, E-1020 significantly increased ATPase activity in bovine (10-100 microM) and canine (1-100 microM) cardiac myofibrils but had no effect on rat cardiac myofibrils. Moreover, in one population of canine ventricular fiber bundles, E-1020 (0.01-10 microM) significantly increased isometric tension at pCa 6.5 and 6.0, whereas in another population of bundles E-1020 had no effect on tension. In no case was resting (pCa 8.0) or maximal tension (pCa 4.5) increased by E-1020. Measurements of Ca2+ binding to canine ventricular skinned fiber preparations demonstrated that E-1020 does not alter the affinity of myofilament troponin C for Ca2+. We conclude that part of the mechanism by which E-1020 acts as an inotropic agent may involve alterations in the responsiveness of contractile proteins to Ca2+. The lack of effect of E-1020 on some preparations may be dependent on isoform populations of myofilament proteins.

show abstract

Hemodynamic efficacy of E-1020 in comparison with dopamine on acute mitral regurgitation in anesthetized dogs.

Cited by 12 publications

References 25 publications

Olprinone: A Phosphodiesterase III Inhibitor with Positive Inotropic and Vasodilator Effects

Olprinone: A Phosphodiesterase III Inhibitor with Positive Inotropic and Vasodilator Effects

E-1020, a water soluble imidazopyridine, has direct effects on Ca2+-dependent force and ATP hydrolysis of canine and bovine cardiac myofilaments

E-1020, a water soluble imidazopyridine, has direct effects on Ca2+-dependent force and ATP hydrolysis of canine and bovine cardiac myofilaments

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