Hemodynamic effects of synthetic atrial natriuretic factor (ANF) in dogs with acute left ventricular failure

Sweet, Charles S.; Ludden, C. T.; Frederick, C. M.; Ribeiro, Lair G.T.; Nussberger, Jürg; Slater, Eve E.; Blaine, Edward H.

doi:10.1016/0014-2999(85)90699-5

Cited by 19 publications

(7 citation statements)

References 16 publications

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“…In the present study, ANP infusion produced either no change or even a slight increase in afterload in rabbits with heart failure, similar to the changes reported for normal rabbits (Woods et al 1989). Studies in two canine heart failure models have similarly failed to elicit arterial vasodilation mediated by ANP (Sweet et al 1985;Riegger et al 1988). The factors underlying this variation in response have not been defined, but the effects ofhypotension are likely to be crucial.…”

Section: Discussionsupporting

confidence: 85%

“…Vasoconstriction in hindlimb vasculature has also been observed in anaesthetized normal rabbits during ANP infusion (Volpe et al 1987). Sweet et al (1985) have shown that ANP infusion improves myocardial blood flow in anaesthetized dogs. In healthy human volunteers, ANP has been shown to increase skin blood flow (Bolli et al 1987).…”

Section: Discussionmentioning

confidence: 97%

“…Responses to exogenous ANP have been studied in two different dog models of heart failure (Sweet et al 1985;Riegger et al 1988). These studies have been unable to repeat the promising haernodynamic benefits obtained when ANP is infused in human CHF.…”

Section: Introductionmentioning

confidence: 99%

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Regional Distribution of the Cardiac Output and Renal Responses to Atrial Atriuretic Peptide Infusion in Rabbits With Congestive Heart Failure

Langton

Jover

Trigg

et al. 1989

Clin Exp Pharma Physio

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1. A biventricular, low-output congestive cardiomyopathy was induced in 19 rabbits by administering adriamycin (16 mg/kg). The effects of alpha-rat atrial natriuretic peptide (ANP) infused at 0.1, 0.2 and 0.4 micrograms/kg per min, were then examined in terms of (i) central haemodynamics (ii) regional blood flow (iii) renal function and (iv) plasma norepinephrine and plasma renin. 2. In this dose range, ANP produced progressive and significant falls in stroke volume, cardiac output and mean arterial pressure, owing to a fall in venous return. The heart rate response to this was blunted. 3. Using radiolabelled microspheres, significant falls in the perfusion of cutaneous, gastrointestinal and musculoskeletal tissues were observed, due to reduced vascular conductances in these beds. These changes were accompanied by activation of the sympathetic nervous system as evidenced by a progressive rise in plasma norepinephrine. A significant increase in plasma renin was only observed with the highest infusion of ANP. 4. Renal blood flow was maintained in the face of a falling mean arterial pressure and cardiac output, but diuretic and natriuretic effects were absent. 5. It was concluded that the dominant influence of ANP infusion in this model of heart failure appeared to be a reduction in cardiac preload with detrimental overall haemodynamic consequences.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 97%

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Regional Distribution of the Cardiac Output and Renal Responses to Atrial Atriuretic Peptide Infusion in Rabbits With Congestive Heart Failure

Langton

Jover

Trigg

et al. 1989

Clin Exp Pharma Physio

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“…One possible explanation for the increase in LV coronary flow of the heart failure group could be that the marked reduction in LVEDP improved diastolic perfllsion pressure in coronary circulation in the face of a limited coronary reserve in the infarcted animals. Indeed, similar increases in coronary blood flow along with a fall in coronary resistance have been observed in dogs with acute left ventricular failure (44).…”

Section: Coronary and Direct-myocardial Effects Of Anpmentioning

confidence: 86%

Systemic and regional vascular effects of atrial natriuretic peptide in a rat model of chronic heart failure

et al. 1987

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To characterize the systemic and regional vascular effects of atrial natriuretic peptide (ANP) in chronic heart failure, central hemodynamics, regional blood flow and plasma ANP levels were determined in a rat model of myocardial infarction and failure and in sham-operated animals. Measurements were made in the conscious state before and after intravenous rANP [99-126] (8 micrograms bolus followed by continuous infusion of 1.0 microgram/kg/min). With this protocol, ANP significantly decreased cardiac output, right atrial, left ventricular end-diastolic and arterial pressures and there were increases in heart rate, systemic and intestinal vascular resistances in sham animals. Renal blood flow per gram of tissue was unchanged with ANP, but when expressed as a percentage of cardiac output, increased significantly, indicating a preferential renal vasodilatory effect of ANP. In rats with infarction and failure, this dose did not alter cardiac output or arterial pressure, but decreased right atrial and left ventricular blood flow. Although significantly reduced as compared to the control group, renal blood flow was not improved with ANP in the heart failure group. ANP plasma levels of the heart failure group were elevated at baseline (p less than 0.01), and increased 5-10 times after infusion of rANP. Thus, in rats with chronic heart failure, the renal vascular effects of ANP are blunted, which may, in part, explain the failure of ANP to restore the altered volume homeostasis in heart failure despite elevated ANP plasma levels. However, the effects on venous return were preserved which, in turn, improved cardiac performance via a reduction of preload.

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“…Other studies in congestive heart failure patients and in animals with congestive heart failure have also demonstrated that short-term infusions of ANF result in an improvement in cardiac output.15-17 It is believed that this improvement in cardiac output is due to the ability of ANF to reduce cardiac afterload through its systemic vasodilatory action. 18 Although numerous studies have examined the short-term effects of exogenous ANF on cardiac function in congestive heart failure, there is very little, if any, published information regarding the cardiovascular effects of NE? inhibition in congestive heart failure.…”

Section: Editorial Comment Inhibitors Of Anf Metabolismmentioning

confidence: 99%

Inhibitors of ANF metabolism. Potential therapeutic agents in cardiovascular disease.

Granger

1990

Circulation

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Hemodynamic effects of synthetic atrial natriuretic factor (ANF) in dogs with acute left ventricular failure

Cited by 19 publications

References 16 publications

Regional Distribution of the Cardiac Output and Renal Responses to Atrial Atriuretic Peptide Infusion in Rabbits With Congestive Heart Failure

Regional Distribution of the Cardiac Output and Renal Responses to Atrial Atriuretic Peptide Infusion in Rabbits With Congestive Heart Failure

Systemic and regional vascular effects of atrial natriuretic peptide in a rat model of chronic heart failure

Inhibitors of ANF metabolism. Potential therapeutic agents in cardiovascular disease.

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