Hemodynamic Effects of Levosimendan on Dexmedetomidine Infusion in Rats Under Isoflurane Anesthesia

Abstract

A An na ah ht ta ar r K Ke el li im me el le er r: : İzofluran; deksmedetomidin; simendan; kalp hızı; kan basıncı; sıçanlar A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : In this study, hemodynamic effects of levosimendan (L) on dexmedetomidine (D) infusion in rats were investigated under isoflurane (I) anesthesia. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : A total of eighteen female Wistar-Albino rats were divided into 3 groups. Rats were artificially respirated following cannulation and tracheostomy. At the end of the stabilization period (15 min), initial hemodynamic values were recorded and (i) I (1.4%) was administered to Group I; (ii) I (1.4%) and D (1 µg/kg/dk) were administered to Group ID and (iii) I (1.4%), D (1 µg/kg/dk) and L (0.3 µg/kg/dk) were administered to Group IDL for 60 min. Heart rate (HR)(bpm), systolic (SAP), diastolic (DAP) and mean arterial pressure (MAP) (mmHg) were recorded with 5 min intervals were and given as mean and/or %. One way variance analysis, Tukey-Kramer and paired t tests were used, p< 0.05 was considered the level of significance. R Re es su ul lt ts s: : No difference was found between groups in terms of initial hemodynamic values. On the contrary, significant differences were found in HR (p= 0.03) and DAP (p= 0.03) at the end of the infusion period between groups. The differences were correlated to the lower HR in Group ID (176) Group I and HR (206 vs. 176 [85%], p= 0.008) decreased significantly in Group ID at the end of the infusion period when compared to baseline values. C Co on nc cl lu us si io on n: : In rats, I led to a decrease in systemic arterial pressure; and D in the presence of I led to a decrease in HR. Isoflurane-related systemic arterial pressure decrease was prevented by using of D and combination of D and L. Additionally, D-related HR decrease in the presence of I was prevented by using L. In this study, positive effects of D and DL utilization were observed when systemic arterial pressure dropped due to I. Besides, positive effect of L utilization was observed when HR decreased due to D in the presence of I in rats.K Ke ey y W Wo or rd ds s: : Isoflurane; dexmedetomidine; simendan; heart rate; blood pressure; rats