Hemodynamic Effects of Gabapentin in Rats

Yoon, Myung Ha; Choi, Jeong Il

doi:10.3346/jkms.2003.18.4.478

Cited by 12 publications

(13 citation statements)

References 20 publications

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“…In our study we found that gabapentin lead to more stabilization of heart rate and mean arterial blood pressure which was an index for pain reduction. while Myung et al found that in rats intrathecal and intraperitoneal gabapentin did not induce significant changes of hemodynamics over the 60 min compared to the baseline value [20]. Mausumi et al found that gabapentin provide hemodynamic stability during laparoscopic surgery in both sexes and this compatible with our study [21].…”

Section: Discussionsupporting

confidence: 81%

Gabapentin as Premedication for Postoperative Analgesia in Children: A Prospective Randomized Controlled Study

Mogahed¹,

Ghaffar²

2017

J Anesth Clin Res

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Section: Discussionsupporting

confidence: 81%

Gabapentin as Premedication for Postoperative Analgesia in Children: A Prospective Randomized Controlled Study

Mogahed¹,

Ghaffar²

2017

J Anesth Clin Res

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“…In a previous study, gabapentin administered at doses of 10, 30, 100 and 300 mg/kg intraperitoneally to Sprague -Dawley rats had no effect on BP or heart rate postadministration. 21 A possible explanation for the lack of any clinically relevant effect of gabapentin on isoflurane MAC might be Table 1 Arterial acid -base and blood gas data, and cardiovascular parameters at baseline and following intraperitoneal saline and gabapentin (30-1000 mg/kg) administration that gabapentin is primarily an analgesic for persistent inflammatory and/or neuropathic pain associated with hyperalgesia 5 and not against acute noxious stimuli such as a tail clamp as was applied in our experiments. Human studies investigating the reduction of perioperative pain or opioid consumption upon the administration of gabapentin have been inconsistent.…”

Section: Discussionmentioning

confidence: 97%

Effects of intraperitoneal administration of gabapentin on the minimum alveolar concentration of isoflurane in adult male rats

2012

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Gabapentin has been used to treat a variety of conditions in both human and veterinary medicine, including seizures, neuropathies and chronic pain. However, little information is known about the effects of gabapentin on the minimum alveolar concentration (MAC) of volatile anaesthetics. In this study, we investigated the effect of intraperitoneal administration of gabapentin on isoflurane MAC in adult male rats and hypothesized that gabapentin would decrease MAC in a dose-dependent manner. Using a standard MAC study protocol, we compared five treatment groups (G) receiving 0 (G(0)), 30 (G(30)), 100 (G(100)), 300 (G(300)) and 1000 (G(1000)) mg/kg gabapentin intraperitoneally and compared post-drug MAC values among groups and with corresponding baseline MAC values determined in each group prior to drug testing. The average baseline isoflurane MAC value was 1.45 ± 0.17%, which did not differ significantly between groups (1.47 ± 0.23% [G(30)], 1.46 ± 0.23% [G(100)], 1.48 ± 0.18% [G(300)] and 1.42 ± 0.2% [G(1000)]). In the G(300) and G(1000) groups, the isoflurane MAC value decreased significantly by 19% and 18%, respectively, from corresponding baseline values (P< 0.05, when compared with G(0)). Linear regression analysis revealed a negative correlation between blood gabapentin concentration and percent change in MAC (R(2) = 0.43; P< 0.05) but not dose. In conclusion, high-dose intraperitoneal gabapentin decreased isoflurane MAC. However, the effect was small and not dose-dependent, and is unlikely to be clinically significant.

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“…Moreover, i.p. administration of gabapentin at doses up to 300 mg/kg in rat did not affect heart rate and blood pressure [68]. For spinal drug administration, 5 µl of saline or gabapentin (200 µg/5 µl) [20; 68] were injected slowly via the intrathecal catheter, followed by a 1 µl air bubble and 9 µl saline flush.…”

Section: Methodsmentioning

confidence: 99%

Multiple sites and actions of gabapentin-induced relief of ongoing experimental neuropathic pain

Bannister

Navratilova

et al. 2017

Pain

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Gabapentin is a first-line therapy for neuropathic pain but its mechanisms and sites of action remain uncertain. We investigated gabapentin-induced modulation of neuropathic pain following spinal nerve ligation (SNL) in rats. Intravenous or intrathecal gabapentin reversed evoked mechanical hypersensitivity, produced conditioned place preference (CPP) and dopamine release in the nucleus accumbens (NAc) selectively in SNL rats. Spinal gabapentin also significantly inhibited dorsal horn wide dynamic range (WDR) neuronal responses to a range of evoked stimuli in SNL rats. In contrast, gabapentin microinjected bilaterally into the rostral anterior cingulate cortex (rACC), produced CPP and elicited NAc dopamine release selectively in SNL rats but did not reverse tactile allodynia and had marginal effects on WDR neuronal activity. Moreover, blockade of endogenous opioid signaling in the rACC prevented intravenous gabapentin-induced CPP and NAc dopamine release but failed to block its inhibition of tactile allodynia. Gabapentin therefore can potentially act to produce its pain relieving effects by (a) inhibition of injury-induced spinal neuronal excitability, evoked hypersensitivity and ongoing pain and (b) selective supraspinal modulation of affective qualities of pain, without alteration of reflexive behaviors. Consistent with previous findings of pain relief from non-opioid analgesics, gabapentin requires engagement of rACC endogenous opioid circuits and downstream activation of mesolimbic reward circuits reflected in learned pain motivated behaviors. These findings support the partial separation of sensory and affective dimensions of pain in this experimental model and suggest that modulation of affective-motivational qualities of pain may be the preferential mechanism of gabapentin’s analgesic effects in patients.

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Hemodynamic Effects of Gabapentin in Rats

Cited by 12 publications

References 20 publications

Gabapentin as Premedication for Postoperative Analgesia in Children: A Prospective Randomized Controlled Study

Gabapentin as Premedication for Postoperative Analgesia in Children: A Prospective Randomized Controlled Study

Effects of intraperitoneal administration of gabapentin on the minimum alveolar concentration of isoflurane in adult male rats

Multiple sites and actions of gabapentin-induced relief of ongoing experimental neuropathic pain

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