Hemodynamic effects of captopril and isosorbide mononitrate started early in acute myocardial infarction: A randomized placebo-controlled study

Pipilis, Athanase; Flather, Marcus; Collins, Rory; Coats, Andrew J.S.; Conway, Michael; Appleby, Paul N.; Sleight, Peter

doi:10.1016/0735-1097(93)90817-k

Cited by 28 publications

(1 citation statement)

References 37 publications

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“…Nitrates can favorably influence myocardial infarction through several mechanisms [78]. They can reduce infarct size through hemodynamic effects and increased collateral flow [79,80].…”

Section: Mechanisms Of Nitrate In Cardioprotectionmentioning

confidence: 99%

Postconditioning with Nitrates Protects Against Myocardial Reperfusion Injury: A New Use for an Old Pharmacological Agent

2020

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Early reperfusion remains the key therapy to salvage viable myocardium and must be applied as soon as possible following an acute myocardial infarction (AMI) to attenuate the ischemic insult. However, reperfusion injury may develop following reintroduction of blood and oxygen to vulnerable myocytes, which results in more severe cell death than in the preceding ischemic episode. Ischemic postconditioning (I-PostC) provides a cardioprotective effect in combination with pharmacological agents. Although nitrates have been tested in many experimental and clinical studies of acute AMI to evaluate the cardioprotective effect, few investigations have been focused on nitrates postconditioning in patients undergoing percutaneous coronary intervention (PCI). This review presents the manifestations of myocardial reperfusion injury (RI) and potential mechanisms underlying it, and provides the mechanisms involved in the cardioprotection of I-PostC. We also present a new therapeutic approach to attenuate RI by use of an 'old' agent -nitrates -in AMI patients.

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“…Nitrates can favorably influence myocardial infarction through several mechanisms [78]. They can reduce infarct size through hemodynamic effects and increased collateral flow [79,80].…”

Section: Mechanisms Of Nitrate In Cardioprotectionmentioning

confidence: 99%

Postconditioning with Nitrates Protects Against Myocardial Reperfusion Injury: A New Use for an Old Pharmacological Agent

2020

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Nitrates in Myocardial Infarction

Jugdutt¹

1997

Nitrates Updated

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Recruitment of Ventricular Function with Adjunctive Nitrate Therapy after Late Reperfusion

Jugdutt¹

1995

Developments in Cardiovascular Medicine

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Hemodynamic effects of captopril and isosorbide mononitrate started early in acute myocardial infarction: A randomized placebo-controlled study

Abstract: This study indicates that the hemodynamic effects of both captopril and isosorbide mononitrate are well tolerated in the acute phase of myocardial infarction and that captopril favorably influences cardiac function.

Cited by 28 publications

References 37 publications

Postconditioning with Nitrates Protects Against Myocardial Reperfusion Injury: A New Use for an Old Pharmacological Agent

Postconditioning with Nitrates Protects Against Myocardial Reperfusion Injury: A New Use for an Old Pharmacological Agent

Nitrates in Myocardial Infarction

Recruitment of Ventricular Function with Adjunctive Nitrate Therapy after Late Reperfusion

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