Hemodynamic Effect of Nifedipine (Adalat) in Patients Catheterized for Coronary Artery Disease

SUMMARYTen mg of Nifedipine, a Ca++ antagonist, was administered orally in 2 groups of patients; Group I: 6 patients in hypertensive emergency and Group II: 12 patients with intractable, severe hypertension. Following results were obtained. 1) A marked hypotensive effect was observed in all patients of Group I. The maximum effect was observed within 30 to 60min and lasted for approximately 180min. Clinical symptoms also improved remarkably with the fall in blood pressure. Any side effect was not observed. 2) A marked hypotensive effect was observed in all cases of Group II. The blood pressure fell by 21.4% systclic (p<0.01) and 19.4% diastolic (p<0.02). The peripheral vascular resistance also showed the decrease by 26.2% (p<0.01). The heart rate and cardiac index increased slightly.It was suggested that the hypotensive mechanism of this preparation is due primarily to the peripheral vasodilatation.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Hemodynamic Effect of Nifedipine (Adalat) in Patients Catheterized for Coronary Artery Disease

Cited by 3 publications

References 0 publications

Inappropriate coronary vasoconstriction in patients with coronary artery disease: A role for nifedipine?

Inappropriate coronary vasoconstriction in patients with coronary artery disease: A role for nifedipine?

Hemodynamic Effects of Sublingual Nifedipine in Congestive Heart Failure

A Study on the Effects of Nifedipine in Hypertensive Crises and Severe Hypertension

Contact Info

Product

Resources

About