Hemodynamic correlates of prolonged thiazide therapy: Comparison of responders and non responders

ACCF/AHA 2011 Expert Consensus Document on Hypertension in the Elderly

“…22 Chlorthalidone differs from HCTZ by its longer duration of action and greater potency, and for this reason, may be associated with a higher risk of metabolic adverse effects. Diuretics cause an initial reduction in intravascular volume, peripheral vascular resistance, [551][552][553] BP in Ͼ50% of patients, and are generally well tolerated and inexpensive. Several trials demonstrate their ability to also reduce CV, cerebrovascular, and renal adverse outcomes in the elderly.…”

ACCF/AHA 2011 Expert Consensus Document on Hypertension in the Elderly

“…Chlorthalidone differs from HCTZ by its longer duration of action and greater potency, and for this reason, may be associated with a higher risk of metabolic adverse effects. Diuretics cause an initial reduction in intravascular volume, peripheral vascular resistance (551)(552)(553), BP in Ͼ50% of patients, and are generally well tolerated and inexpensive. Several trials demonstrate their ability to also reduce CV, cerebrovascular, and renal adverse outcomes in the elderly.…”

Clinical Pharmacology of Antihypertensive Therapy for the Treatment of Hypertension in CKD

“…Thiazide diuretics reduce BP acutely by causing natriuresis, thereby reducing extracellular volume, venous return, and ultimately, cardiac output. However, in the setting of chronic thiazide administration, cardiac output has been shown to return to the pretreatment baseline and total peripheral resistance falls, maintaining the net antihypertensive effect (38,39) The mechanism that causes the fall in total peripheral resistance is unknown but may be related to a slight reduction in volume. In the setting of chronic volume expansion, such as ESKD, an increased cardiac output culminates in increased peripheral resistance and hypertension (40).…”