BACKGROUND: Laparoscopic cholecystectomy offers many benefits but significant hemodynamic changes are observed, which can be detrimental especially in elderly and hemodynamically compromised patients. Clonidine was found to inhibit the release of catecholamines and vasopressin and thus modulate the haemodynamic changes induced by pneumoperitoneum. AIM AND OBJECTIVES OF THE STUDY: To assess the efficacy of intravenous clonidine premedication in prevention of adverse haemodynamic changes during laparoscopic cholecystectomy. The following parameters were studied. Heart rate and Blood pressure response to induction, intubation and pneumoperitoneum. Requirements of intra-op analgesia like Fentanyl. Incidence of post-op nausea and vomiting Incidence of shivering. METHODS: 100 patients undergoing elective laparoscopic cholecystectomy were randomly assigned to one of the two groups to receive either clonidine 4 micrograms per kg or equivalent quantity of normal saline The primary outcome was to assess the efficacy of intravenous clonidine premedication in prevention of adverse haemodynamic changes during laparoscopic cholecystectomy. STATISTICAL METHODS: Student t test (two tailed, independent) has been used to find the significance of study parameters (HR, SBP, DBP) on continuous scale between two groups (Inter group analysis) and to test the homogeneity samples based on age (continuous parameters). Chi-square test was used to test the homogeneity of samples based on parameters on categorical scale between two groups. P<0.05 was considered as statistically significant. The statistical software namely SPSS 15.0, Stata 8.0, Med Calc 9.0.1 and Systat 11.0 were used for the analysis of the data and Microsoft word and Excel have been used to generate graphs, tables etc. RESULTS: The result showed that Blood Pressure (SBP, DBP, MAP) and HR in study group fell significantly to lower level within 10 minutes after starting clonidine infusion and remained significantly low during laryngoscopy and intubation, pneumoperitoneum and extubation (P<0.001). CONCLUSION: Premedication with 4μg/kg body weight of intravenous clonidine has been found to be safe and effective method that provides stable hemodynamics and protection against stress response triggered by pneumoperitoneum in patients undergoing laparoscopic cholecystectomy. It also brings down the incidence of post-operative complications such as nausea, vomiting and shivering