Hemodynamic Changes in the Treatment of Multiple Intracranial Aneurysms: A Computational Fluid Dynamics Study

Thenier-Villa, José Luis; Rodríguez, A; Martínez-Rolán, Rosa María; Gelabert-González, Miguel; González-Vargas, Pedro Miguel; Campoverde, Raúl Alejandro Galarraga; Molina, Jorge Díaz; Zaragoza, Adolfo de la Lama; Martínez-Cueto, P.; Pou, J.; Alonso, Cesáreo Conde

doi:10.1016/j.wneu.2018.07.009

Cited by 6 publications

(2 citation statements)

References 32 publications

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“…The development and rupture of aneurysms are well established to be relatively significant for WSS and pressure. 11,39,40 Current studies also showed that aneurysm projected posteriorly would enhance the stress and pressure at the neck region of aneurysm, even with small sizes as small as 1.9 mm, which may contribute to the rupture of aneurysms. However, this kind of aneurysm growing behind A1 segment is blocked by blood vessels, causing inconvenience to surgical diagnosis and treatment.…”

Section: Discussionmentioning

confidence: 99%

Hemodynamic impact of proximal anterior cerebral artery aneurysm: Mind the posteriorly projecting ones!

Fan

Liang

Zhang

et al. 2022

Proc Inst Mech Eng H

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Intracranial aneurysm projected posteriorly is associated with high risk of aneurysm rupture. In order to investigate the biomechanical mechanisms for the adverse event, three-dimension intracranial cerebral aneurysms were constructed based on clinical data, and we numerically compared effect of location, position, size, and shape of aneurysm on hemodynamic conditions including velocity, pressure, and wall shear stress (WSS). The numerical results showed that the aneurysm projected posteriorly even at small sizes led to abnormal hemodynamic environment, which was featured by a local high pressure and stress concentration near aneurysm neck area. Moreover, the one located at the proximal A1 segment and ellipsoidal aneurysm would further worse local hemodynamic environment, causing high local stresses. These findings indicated the potential mechanical mechanism for high rupture rate of the aneurysms projected posteriorly, underscoring importance of early and accurate diagnosis and promptly treatment for improved the clinical outcome, even if these aneurysms are of small sizes.

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Section: Discussionmentioning

confidence: 99%

Hemodynamic impact of proximal anterior cerebral artery aneurysm: Mind the posteriorly projecting ones!

Fan

Liang

Zhang

et al. 2022

Proc Inst Mech Eng H

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“…Imai et al [5] suggested that it is important to consider arterial geometry and secondary flow in the design of endovascular devices by analysing the steady-state inflow for aneurysms. Thenier et al [6] carried out the research work considering the patient-specific cases and observed the presence of lower wall shear stress in the ruptured aneurysms. The study conducted by Sano et al [7] highlights the relevance of the idealised model to reveal the hemodynamic characteristics to understand the rupture status.…”

Section: Introductionmentioning

confidence: 99%

Effect of dome size on flow dynamics in saccular aneurysms – A numerical study

Nayak

Kumar

Khader

et al. 2020

JMES

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Image-based Computational Fluid Dynamic (CFD) simulations of anatomical models of human arteries are gaining clinical relevance in present days. In this study, CFD is used to study flow behaviour and hemodynamic parameters in aneurysms, with a focus on the effect of geometric variations in the aneurysm models on the flow dynamics. A computational phantom was created using a 3D modelling software to mimic a spherical aneurysm. Hemodynamic parameters were obtained and compared with the available literature to validate. Further, flow dynamics is studied by varying the dome size of the aneurysm from 3.75 mm to 6.25 mm with an increment of 0.625 mm keeping the neck size constant. The aneurysm is assumed to be located at a bend in the arterial system. Computational analysis of the flow field is performed by using Navier – Stokes equation for laminar flow of incompressible, Newtonian fluid. Parameters such as velocity, pressure, wall shear stress (WSS), vortex structure are studied. It was observed that the location of the flow separation and WSS vary significantly with the geometry of the aneurysm. The reduction of WSS inside the aneurysm is higher at the larger dome sizes for constant neck size.

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Current Management of Mirror Distal Anterior Cerebral Artery Aneurysms in Association with Multiple Aneurysms: Case Report with Literature Review

et al. 2019

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Hemodynamic Changes in the Treatment of Multiple Intracranial Aneurysms: A Computational Fluid Dynamics Study

Cited by 6 publications

References 32 publications

Hemodynamic impact of proximal anterior cerebral artery aneurysm: Mind the posteriorly projecting ones!

Hemodynamic impact of proximal anterior cerebral artery aneurysm: Mind the posteriorly projecting ones!

Effect of dome size on flow dynamics in saccular aneurysms – A numerical study

Current Management of Mirror Distal Anterior Cerebral Artery Aneurysms in Association with Multiple Aneurysms: Case Report with Literature Review

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