Hemodynamic Changes in Salt Depletion and in Dehydration

The Effects of an Increase in Plasma Volume on the Metabolism and Excretion of Water and Electrolytes by Normal Subjects 12

“…The chemical methods and calculations have been described in previous publications from this department (6)(7)(8)(9). In the calculations the value for the initial volume of extracellular fluid (chloride space) was assumed to be 20% of the body weight.…”

Effects of Injection of Hypertonic Glucose on Metabolism of Water and Electrolytes in Patients With Edema 1

“…Balance data were calculated using methods and assumptions previously described from this department (1,8). Changes in extracellular volume were estimated from alterations in the chloride balance after assuming an initial extracellular volume of 35% of the body weight.…”

John P. Peters and nephrology

“…With Elkinton, Danowski, and Winkler, he investigated key aspects of the physiological state and treatment of saltdepletion shock [13]. His associates made the important (and still unexplained) observation that when hyponatremia accompanies circulatory shock, protein is lost from the circulating bloodstream much more rapidly than when the serum sodium level is normal, thus providing a rationale for the correction of hyponatremia with hypertonic saline in the presence of hypotension.…”