Hemodynamic and metabolic responses to exercise after adrenoceptor blockade in humans

McLeod, A. A.; Brown, J. E.; Kitchell, BB; Sedor, Frank A.; Kuhn, Cynthia M.; Shand, David G.; Williams, R. Sanders

doi:10.1152/jappl.1984.56.3.716

Cited by 31 publications

(15 citation statements)

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“…Although there was a further increase in Vo^ax between Sessions 3 and 4 that was restricted to the atenolol group, this differential change across groups was not sufficiently pronounced to lead to a significant difference among the groups at Session 4. The present results thus demonstrate that hypertensive subjects resemble normotensive subjects 13 in their ability to achieve benefits in cardiorespiratory fitness, despite the presence of either nonselective or selective /3-blockade. The differences between atenolol and propranolol in their physiological properties 20 did not lead, during long-term administration, to differential effects in the increase in Vo 2 max associated with aerobic exercise training.…”

Section: Discussionsupporting

confidence: 53%

“…/3-Blockade has been found to lead to some deficits during tests of memory (i.e., Wechsler-Russell Memory Scale), 13 and on RT measures of sensory and motor functioning. ' 6i " Miller et al, 18 in contrast, observed that hypertensive subjects improved their performance of cognitive tasks when blood pressure was normalized by pharmacological treatment.…”

Section: -Blockade Exercise and Memory/madden Et Almentioning

confidence: 99%

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Effects of beta-blockade and exercise on cardiovascular and cognitive functioning.

1988

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SUMMARY Twenty-four men with mild essential hypertension were assigned randomly to receive propranolol (n = 9), atenolol (n = 7), or a placebo (n = 8). All subjects participated in a 12-week study and provided physiological and behavioral data four times during the study: after a medication-free baseline period (Session 1); after 2 weeks of medication, without exercise (Session 2); after 8 weeks of continued medication while participating in a program of aerobic exercise (Session 3); and after 2 weeks of maintenance exercise without medication (Session 4). Subjects 9 maximal oxygen uptake increased significantly between Sessions 2 and 3, and the magnitude of this increase did not vary across the drug groups. Subjects' resting heart rates varied as a function of the presence of ^-blocking medication, but there was in addition a reduction attributable to exercise training that did not vary across the drug groups. The decrease in blood pressure associated with 0-blockade (Session 2) was not decreased any further by exercise training (Session 3). Despite an increase in blood pressure following the withdrawal of active medication (Session 4), blood pressure remained significantly lower compared with the Session 1 baseline level. Performance in a reaction-time test of short-term memory functioning improved slightly for all three groups between Sessions 1 and 2 and remained constant thereafter. The present findings demonstrate that hypertensive persons can achieve cardiorespiratory training effects despite the presence of 0-blockade, that the combined effects of aerobic exercise training and ^-blockade do not influence performance on this test of memory functioning, and that aerobic exercise may be a useful complement to pharmacological methods for maintaining reductions in blood pressure. (Hypertension 11: 470-476, 1988) KEY WORDS • hypertension • 0-blockade • aerobic exercise • cognitive processes H YPERTENSION is a major cardiovascular disease affecting 25% of the adult population in the United States. 1 The physical consequences of hypertension include end-organ damage that can lead to kidney failure, stroke, and coronary heart disease.2 Hypertension may have behavioral consequences as well.3 In particular, hypertension-related deficits have been observed both on psychometric

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Section: Discussionsupporting

confidence: 53%

Section: -Blockade Exercise and Memory/madden Et Almentioning

confidence: 99%

Effects of beta-blockade and exercise on cardiovascular and cognitive functioning.

1988

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“…In the present study, neither propranolol nor atenolol modified oxygen consumption or carbon dioxide production. Our previous investigations however have strongly suggested that propranolol but not atenolol impairs hepatic glucose release (McLeod et al, 1983(McLeod et al, , 1984 (Felig & Wahren, 1975). There is evidence for enhanced intramuscular glycogenolysis during exercise after propranolol which would support this concept (Juhlin-Dannfelt et al, 1982).…”

Section: Discussionmentioning

confidence: 95%

Beta 1‐selective and non‐selective beta‐adrenoceptor blockade, anaerobic threshold and respiratory gas exchange during exercise.

McLeod¹,

Knopes²,

Shand³

et al. 1985

Brit J Clinical Pharma

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1 The effect of oral doses of the pl-selective adrenoceptor antagonist atenolol (50 mg), the non-selective antagonist propranolol (40 mg) and placebo was investigated during exercise in a crossover comparison in six healthy but untrained subjects. Descriptors of ventilation, respiratory gas exchange, and arterialized blood lactate and glucose were obtained during steady state bicycle ergometric exercise at 20% and 60% of the subjects' previously determined maximal oxygen uptake (Vo2 max). 2 At these work intensities, the previously reported increase of respiratory exchange ratio (RER) during non-selective 3-adrenoceptor blockade was found to be trivial (placebo = 0.96 ± 0.03 s.e. mean; propranolol = 0.97 + 0.01; atenolol = 0.97 + 0.04; 60% Vo2 max, 10 min exercise) and only present during the early minutes of effort.Oxygen uptake and carbon dioxide production did not differ between treatments. 3 Both drugs produced highly significant falls in peak expiratory flow (PEF) rates and tidal volume (VT) which were compensated by an increase in respiratory rate. PEF, 60% Vo2 max: placebo = 3.8 + 0.3 l/s; propranolol 3.6 + 0.3 1/s (P < 0.03); atenolol 3.1 + 0.3 1/s (P < 0.01). VT, 60% Vo2 max: placebo 2.0 + 0.1 1; propranolol 1.8 + 0.2 1 (P < 0.05); atenolol 1.7 ± 0.1 1 (P < 0.01). 4 Arterialized lactate was significantly elevated during work at 20% and 60% Vo2 max, but rose progressively at the 60% Vo2 max load. Ventilation, oxygen uptake and ventilatory equivalent for carbon dioxide also rose progressively at this workload. Ventilatory equivalent for oxygen showed no significant rise. There were no treatment differences, either at the aerobic or anaerobic workloads. During steady state exercise, previously described determinants of anaerobic threshold (RER, 02 ventilatory equivalent) appear not to be valid. 5 We conclude that normoglycaemic aerobic or anaerobic work is associated with a I3l-adrenoceptor response which reduces airway resistance. Despite antagonism of lipolysis and hepatic glycogenolysis, ,B-adrenoceptor blockade does not appear to alter the pattern of substrate utilization.

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“…McLeod et al [6] noted that exercise on healthy human males affected the hemodynamic and metabolic actions of propranolol, atenolol and prazosin.…”

Section: (If Applicable)mentioning

confidence: 99%

Investigation of Guinea Pig Performance on an Eight-Lane Treadmill

Finger¹

1991

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Hemodynamic and metabolic responses to exercise after adrenoceptor blockade in humans

Cited by 31 publications

References 0 publications

Effects of beta-blockade and exercise on cardiovascular and cognitive functioning.

Effects of beta-blockade and exercise on cardiovascular and cognitive functioning.

Beta 1‐selective and non‐selective beta‐adrenoceptor blockade, anaerobic threshold and respiratory gas exchange during exercise.

Investigation of Guinea Pig Performance on an Eight-Lane Treadmill

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