Hemodynamic and metabolic responses to neuronal inhibition

Stefanović, Bojana; Warnking, Jan; Pike, G. Bruce

doi:10.1016/j.neuroimage.2004.01.036

Cited by 287 publications

(258 citation statements)

References 42 publications

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“…This tendency was particularly pronounced for the negative boxcar component. A negative BOLD response is well known in M1 for ipsilateral motor activity [28,40] or in ipsilateral S1 and bilateral M1 for unilateral somatosensory stimulation [41]. However, it has not previously been reported that this negative response is predominantly linear with respect to stimulus length.…”

Section: Discussionmentioning

confidence: 99%

Transient and sustained components of the sensorimotor BOLD response in fMRI

Marxen

Cassidy

Dawson

et al. 2012

Magnetic Resonance Imaging

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Blood oxygenation level-dependent (BOLD) signal time courses in functional magnetic resonance imaging are estimated within the framework of general linear modeling by convolving an input function, that represents neural activity, with a canonical hemodynamic response function (HRF). Here we investigate the performance of different neural input functions and latency-optimized HRFs for modeling BOLD signals in response to vibrotactile somatosensory stimuli of variable durations (0.5, 1, 4, 7 s) in 14 young, healthy adults who were required to make button press responses at each stimulus cessation. Informed by electrophysiology and the behavioral task, three nested models with an increasing number of parameters were considered: a boxcar; boxcar and offset transient; and onset transient, boxcar and offset transient (TBT). The TBT model provided the best fit of the group-averaged BOLD time courses based on χ 2 and F statistics. Only the TBT model was capable of fitting the bimodal shape of the BOLD response to the 7-s stimulus and the relative peak amplitudes for all stimulus lengths in key somatosensory and motor areas. This suggests that the TBT model provides a more comprehensive description of brain sensorimotor responses in this experiment than provided by the simple boxcar model. Work comparing the activation maps obtained with the TBT model with magnetoencephalography data is under way.

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Section: Discussionmentioning

confidence: 99%

Transient and sustained components of the sensorimotor BOLD response in fMRI

Marxen

Cassidy

Dawson

et al. 2012

Magnetic Resonance Imaging

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show abstract

“…However, at the level of individual neurons, both excitation and inhibition are taking place in both NBR and PBR. The terms 'excitatory' and 'inhibitory' are thus used here to describe the stimulation paradigms and their response with regard to their net response within the considered brain regions analogous to earlier studies (Stefanovic et al, 2004).…”

Section: Methodsmentioning

confidence: 99%

“…Further studies (Kennerley et al, 2012b;Pasley et al, 2007) leave no room for non-neurally driven CBF contributions to NBR, and suggest that neurovascular coupling is conserved for both the positive and negative BOLD responses. There is now a general consensus that the NBR is accompanied by decreases in CBF and CMRO 2 , as shown with fMRI in human visual and motor cortex (Pasley et al, 2007;Shmuel et al, 2002;Stefanovic et al, 2004), with fMRI in monkey visual cortex (Shmuel et al, 2006), and with fMRI and optical imaging spectroscopy (OIS) in rat somatosensory cortex (Boorman et al, 2010;Kennerley et al, 2012b). …”

Section: Introductionmentioning

confidence: 96%

Investigation of the neurovascular coupling in positive and negative BOLD responses in human brain at 7T

et al. 2014

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“…The scaling parameter M is proportional to the product of baseline deoxyhemoglobin content, echo time and a field strength proportionality constant and physiologically represents the maximal BOLD signal available upon washout of all deoxyhemoglobin (Davis, et al 1998;Hoge et al 1999a; ). The few studies using the calibrated-BOLD fMRI approach found n values ranging from 2-4 (Davis et al 1998;Hoge et al 1999a; Kastrup et al 2002;Kim et al 1999;St Lawrence et al 2003;Stefanovic et al 2004;). …”

Section: Introductionmentioning

confidence: 99%

Reproducibility of BOLD, perfusion, and CMRO2 measurements with calibrated-BOLD fMRI

2007

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The coupling of changes in cerebral blood flow (CBF) and cerebral metabolic rate of oxygen (CMRO 2 ) during brain activation can be characterized by an empirical index, n, defined as the ratio between fractional CBF change and fractional CMRO 2 change. The combination of blood oxygenation level dependent (BOLD) imaging with CBF measurements from arterial spin labeling (ASL) provides a potentially powerful experimental approach for measuring n, but the reproducibility of the technique previously has not been assessed. In this study, inter-subject variance and intrasubject reproducibility of the method were determined. Block design %BOLD and %CBF responses to visual stimulation and mild hypercapnia (5% CO 2 ) were measured, and these data were used to compute the BOLD scaling factor M, %CMRO 2 change with activation, and the coupling index n. Reproducibility was determined for three approaches to defining regions-of-interest (ROIs): 1) Visual area V1 determined from prior retinotopic maps, 2) BOLD-activated voxels from a separate functional localizer, and 3) CBF-activated voxels from a separate functional localizer. For estimates of %BOLD, %CMRO 2 and n, intra-subject reproducibility was found to be best for regions selected according to CBF activation. Among all fMRI measurements, estimates of n were the most robust and were substantially more stable within individual subjects (coefficient of variation, CV=7.4%) than across the subject pool (CV=36.9%). The stability of n across days, despite wider variability of CBF and CMRO 2 responses, suggests that the reproducibility of blood flow changes is limited by variation in the oxidative metabolic demand. We conclude that the calibrated BOLD approach provides a highly reproducible measurement of n that can serve as a useful quantitative probe of the coupling of blood flow and energy metabolism in the brain.

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Hemodynamic and metabolic responses to neuronal inhibition

Cited by 287 publications

References 42 publications

Transient and sustained components of the sensorimotor BOLD response in fMRI

Transient and sustained components of the sensorimotor BOLD response in fMRI

Investigation of the neurovascular coupling in positive and negative BOLD responses in human brain at 7T

Reproducibility of BOLD, perfusion, and CMRO2 measurements with calibrated-BOLD fMRI

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