1982
DOI: 10.1016/s0002-9149(82)80015-5
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Hemodynamic and gas exchange effects of intravenous diltiazem in patients with pulmonary hypertension

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Cited by 57 publications
(5 citation statements)
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“…In patients with acute respiratory failure, we did not observe any deleterious effect of diltiazem on the pulmonary gas exchange or ventilation-perfusion distribution as assessed by arterial pO2. This is in agreement with a small previous study that demonstrated the lack of worsening of pulmonary gas exchange after pulmonary vasodilatation induced by intravenous diltiazem in patients with pulmonary hypertension [17].…”
Section: Safetysupporting
confidence: 94%
“…In patients with acute respiratory failure, we did not observe any deleterious effect of diltiazem on the pulmonary gas exchange or ventilation-perfusion distribution as assessed by arterial pO2. This is in agreement with a small previous study that demonstrated the lack of worsening of pulmonary gas exchange after pulmonary vasodilatation induced by intravenous diltiazem in patients with pulmonary hypertension [17].…”
Section: Safetysupporting
confidence: 94%
“…1999) and two clinical studies had also shown a reduction of PH in patients after diltiazem administration (Kambara et al . 1981; Crevey et al . 1982).…”
Section: Discussionmentioning
confidence: 99%
“… 44 , 46 , 47 On the other hand, occurrence of life-threatening hemodynamic compromise has often been documented in CCB testing (nifedipine and verapamil). 48 51 Therefore, it is accepted that CCBs should not be used for acute testing. 3 , 42 In contrast, intravenous CCB nicardipine might be useful for acute testing, 52 because the drug is short-acting compared to nifedipine and more vasoselective than other CCBs.…”
Section: Acute Vasoreactivity Testingmentioning
confidence: 99%