Hemodiyaliz Hastalarında Mortaliteye Etkisi Olan Kan Parametreleri ve Ekokardiyografi Bulguları

Abstract

Aim: To determine demographic characteristics, concomitant diseases, relationships between mortality and laboratory test parameters and echocardiography findings.
 Material and Method: Between July 2017 and July 2021, 755 patients who were undergoing hemodialysis because of chronic kidney disease regularly were inspected retrospectively. Patients under 18 years of age and patients who were undergoing hemodialysis for less than two months were excluded.
 Results: Age over 65 years, increased levels of C-reactive protein, ferritin, red cell diameter width, alkaline phosphatase, and decreased levels of albumin, calcium, total protein and low ejection fraction (EF) in echocardiography were found to have significant relationships. There were correlation between mortality and age, albumin levels, existence of hypertension, hyperlipidemia and low EF values. 
 Conclusion: Advanced age, low albumin levels and low EF values and existence of hyperlipidemia and hypertension result in increased risk of mortality in hemodialysis patients. These patients must be carefully monitored. Anti-hypertensive medications have protective effects, and must be preferred whenever possible in hemodialysis patients.

Prognostic value of inflammatory markers for mortality in hemodialysis patients: a retrospective study with over 3-year follow-up

“…In a previous study from Turkey, mortality rate in hemodialysis patients was reported to be 39.2% during 4-year follow-up. 2 In United States Renal Data System, the mortality rate in 2016 was 166 per 1,000 patientyears for hemodialysis patients. 1 In a study from Japan, all-cause mortality rate among hemodialysis patients was 29.1% during 42-month follow-up.…”

“…1,2 Some factors such as age, albumin levels, comorbid conditions, underlying kidney disease, cardiovascular and psychosocial status, residual renal function, dietary factors, etc, may affect mortality rates in hemodialysis patients. 2,3 In CKD patients, chronic systemic inflammation has multifactorial etiology; it contributes to premature ageing and morbidity (especially cardiovascular disease, malnutrition and anemia) and it is a predictor of all-cause mortality. 4 In some previous studies in hemodialysis patients, it was reported that the increased systemic inflammation-based prognostic scores including Glasgow prognostic score and modified Glasgow prognostic score (inflammation-based scores based combination of albumin and CRP levels), neutrophilto-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), prognostic index and prognostic nutritional index were associated with mortality during 42-month follow-up; and inflammation scores, which include NLR, monocyte-to-lymphocyte ratio and PLR, might be useful in predicting prognosis and all-cause mortality.…”