Hemodialysis Leads to Better Survival in Patients with Diabetes or High Comorbidity, Compared to Peritoneal Dialysis

Chang, Jae Hyun; Sung, Ji Yoon; Ahn, Shin Young; Ko, Kwang Pil; Ro, Han; Jung, Ji Yong; Lee, Hyun Hee; Chung, Wookyung; Kim, Sejoong

doi:10.1620/tjem.229.271

Cited by 11 publications

(6 citation statements)

References 18 publications

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“…In addition, chronic bio-incompatible reactions to the dialysis membrane, back filtration of bacterial lipopolysaccharide particles, and dialysate or water contamination with endotoxin are mechanisms that can trigger inflammatory reactions to dialysis. 36 …”

Section: Discussionmentioning

confidence: 99%

The Nationwide Incidence of Retinal Vein Occlusion Following Dialysis due to End-stage Renal Disease in Korea, 2004 through 2013

et al. 2021

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Background We investigated the incidence and risk of retinal vein occlusion (RVO) in end-stage renal disease (ESRD) patients on dialysis in Korea. Methods In this nationwide cohort study, we used Korean National Health Insurance Service data between 2004 and 2013 for analysis. ESRD patients who started dialysis from 2004 to 2013 and an equal number of controls were selected through propensity score matching. RVO incidence in both cohorts were calculated for 2004–2013 using washout data from 2003. The multivariable Cox proportional hazards model was used to assess the risk of RVO in dialysis cohort. The Kaplan-Meier method was used to generate the cumulative RVO incidence curve. Whether the dialysis modality affects the development of RVO was also evaluated. Results In this study, 74,551 ESRD patients on dialysis and the same number of controls were included. The incidence of RVO was significantly higher in the dialysis cohort than in the control cohort (dialysis = 7.3/1,000 person-years [PY]; control = 1.9/1,000 PY; P < 0.001). The cumulative-incidence of RVO was also significantly higher in the dialysis cohort than in the control cohort ( P < 0.001; log-rank test). However, there was no significant difference in the incidence of RVO between the two dialysis methods ( P = 0.550; log-rank test). Conclusion This study provided epidemiological evidence that receiving dialysis for ESRD could increase the risk of developing RVO. We also found a rapid increase in the incidence of RVO with a longer dialysis period. These results strengthen the relationship between retinal vascular disease and renal function.

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Section: Discussionmentioning

confidence: 99%

The Nationwide Incidence of Retinal Vein Occlusion Following Dialysis due to End-stage Renal Disease in Korea, 2004 through 2013

et al. 2021

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“…19 In addition, chronic bioincompatible reactions to the dialysis membrane, back filtration of bacterial lipopolysaccharide particles, and dialysate contamination with endotoxin are mechanisms that can trigger inflammatory reactions in dialysis patients. 20,25 There are various other factors related to dialysis, which may also be associated with RAO development, such as oxidative stress (OS) and hyperhomocysteinemia. Oxidative stress appears in ESRD and is worsened by HD because of the accumulation of oxidative products and the loss of antioxidant molecules.…”

Section: Discussionmentioning

confidence: 99%

“…Regarding PD, dialysate solution-related factors (e.g., hyperglycemia, unfavorable lipid profile, and oxidative stress) and PD catheter-induced chronic inflammation can cause atherosclerosis. 19,20,27 Therefore, although the underlying pathogenic mechanism of atherosclerosis formation might be different, both methods could increase atherosclerosis formation, explaining why there is no difference in the incidence of RAO between the two methods.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…[16][17][18] Therefore, the incidence of RAO could be increased in patients who have undergone dialysis. Additionally, as hemodynamic changes might be different according to the dialysis method, [19][20][21] the RAO incidence might be different according to the method used (hemodialysis [HD] vs. peritoneal dialysis [PD]). However, a largescale, nationwide, long-term cohort study has not been implemented to analyze these factors.…”

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confidence: 99%

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Hemodialysis Leads to Better Survival in Patients with Diabetes or High Comorbidity, Compared to Peritoneal Dialysis

Cited by 11 publications

References 18 publications

The Nationwide Incidence of Retinal Vein Occlusion Following Dialysis due to End-stage Renal Disease in Korea, 2004 through 2013

The Nationwide Incidence of Retinal Vein Occlusion Following Dialysis due to End-stage Renal Disease in Korea, 2004 through 2013

The Nationwide Incidence of Retinal Artery Occlusion Following Dialysis as a Result of End-Stage Renal Disease

Comparison of cardiovascular mortality in hemodialysis versus peritoneal dialysis

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