Hemodialysis-associated amyloidosis of bone of beta-2 microglobulin origin

Mikawa, Yoshihiro; Watanabe, Ryoji; Yamano, Yoshiki

doi:10.1007/bf00439390

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Ubiquitln Ln Neurodegenerative Dlseases1

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1992

1993

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Cited by 4 publications

(1 citation statement)

References 16 publications

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“…For further information on AA amyloid see sections 1.1.6 and 1.4.3. Chronic hemodialysis is usually associated with 02-microglobulin amyloid which primarily deposits as cystÎc bone lesions (Mikawa et al 1990, Zingraff et al 1990). B2-microglobulin may also complicate chronic peritoneal dialysis (Brown et al 1990).…”

Section: Ubiquitln Ln Neurodegenerative Dlseasesmentioning

confidence: 99%

Amyloid enhancing factor activity is associated with ubiquitin

Alizadeh-Khiavi

Normand

Chronopoulos

et al. 1992

Vichows Archiv A Pathol Anat

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Section: Ubiquitln Ln Neurodegenerative Dlseasesmentioning

confidence: 99%

Amyloid enhancing factor activity is associated with ubiquitin

Alizadeh-Khiavi

Normand

Chronopoulos

et al. 1992

Vichows Archiv A Pathol Anat

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Amyloid Destructive Spondyloarthropathy Causing Cord Compression

et al. 1993

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Destructive spondyloarthropathy is a recently recognized disease that has not been reported in the neurosurgical literature. It is associated with spinal amyloid deposition in long-term renal failure and dialysis, and it occurs increasingly as the number of dialysis patients and their survival times increase. Clinically, there is a multisegmental and often rapidly progressive radiculomyelopathy that may require emergency stabilization. The radiological features are disc space narrowing with erosion of vertebral end plates and subarticular cysts. The pathological features include deposition of amyloid, which stains with Congo Red and antibodies to beta-2-microglobulin. We present two cases with clinical, radiological, and pathological features and a review of the literature.

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Destructive Spondyloarthropathy in a Patient on Continuous Ambulatory Peritoneal Dialysis for 13 Years

et al. 1993

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Since 1984 there have been reports of a destructive spondyloarthropathy occurring in patients on long-term hemodialysis. The primary abnormality appears to be an accumulation of β2-microglobulin, which is not adequately removed by dialysis, and forms amyloid deposits in articular and periarticular tissues. We report a case of this disease in a patient treated only by peritoneal dialysis. While this form of treatment may delay the development of arthropathy, as compared to hemodialysis, it does not prevent it. An increasing incidence of this disorder may be expected, since increasing numbers of patients have been on long-term peritoneal dialysis.

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Hemodialysis-associated amyloidosis of bone of beta-2 microglobulin origin

Cited by 4 publications

References 16 publications

Amyloid enhancing factor activity is associated with ubiquitin

Amyloid enhancing factor activity is associated with ubiquitin

Amyloid Destructive Spondyloarthropathy Causing Cord Compression

Destructive Spondyloarthropathy in a Patient on Continuous Ambulatory Peritoneal Dialysis for 13 Years

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