2020
DOI: 10.14814/phy2.14601
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Hemodialysis and erythrocyte epoxy fatty acids

Abstract: Fatty acid products derived from cytochromes P450 (CYP) monooxygenase and lipoxygenase (LOX)/CYP ω/(ω‐1)‐hydroxylase pathways are a superclass of lipid mediators with potent bioactivities. Whether or not the chronic kidney disease (CKD) and hemodialysis treatments performed on end‐stage renal disease (ESRD) patients affect RBC epoxy fatty acids profiles remains unknown. Measuring the products solely in plasma is suboptimal. Since such determinations invariably ignore red blood cells (RBCs) that make up 3 kg of… Show more

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Cited by 2 publications
(6 citation statements)
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“…Moreover, similar results were found for free erythrocyte epoxy-metabolites (Table 3B). Together, the findings indicate that CYP epoxy-metabolites are unequally hydrolyzed by sEH in arterial and venous blood in vivo [14,18]. However, there is no arteriovenous difference in the erythro-epoxides before hemodialysis.…”
Section: Tablementioning
confidence: 72%
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“…Moreover, similar results were found for free erythrocyte epoxy-metabolites (Table 3B). Together, the findings indicate that CYP epoxy-metabolites are unequally hydrolyzed by sEH in arterial and venous blood in vivo [14,18]. However, there is no arteriovenous difference in the erythro-epoxides before hemodialysis.…”
Section: Tablementioning
confidence: 72%
“…Sample preparation and preprocessing, standardization, HPLC-MS detection and data processing were performed as described in [15,16]. All samples were analyzed for free and total RBC fatty acid metabolites [14,17].…”
Section: Sample Pre-processing and Data Analysismentioning
confidence: 99%
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