Hemocompatibility of titanium oxide films

Huang, Nan; Yang, Ping; Leng, Y.X.; Chen, Junying; Sun, Hong; Wang, Jianxin; Wang, Guangjun; Peidao, Ding; Xi, Tao; Leng, Yang

doi:10.1016/s0142-9612(03)00046-2

Cited by 383 publications

(278 citation statements)

References 25 publications

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“…5d are completely wettable by these fluids. This seems to be in accordance with the findings in the references [30,31], which claim that oxidized Ti surfaces are hemocompatible.…”

Section: Discussionsupporting

confidence: 93%

“…For this, the cells were fixed with 6% glutardialdehyde (GA; Merck, Darmstadt, Germany) in PBS (phosphate buffered saline) over night followed by dehydration by means of ascending ethanol series (30,40,50,70,80, 90, 96%, 3 × 100%) 30 min each. Then, the samples were transferred into 100% hexamethyl-disilazane (HMDS; Merck).…”

Section: Electron Microscopy Of Cell Covered Surfacesmentioning

confidence: 99%

“…The thickness, composition, crystallinity, and charge distribution of the Ti-O films influence strongly their interaction with cells and other biological materials. For instance, it has been shown that oxide layers formed by ion implantation, sputtering, or ion beam enhanced deposition provided a good hemocompatibility of Ti surfaces [30,31]. Proteins adsorbed on an oxidized Ti substrate prior to its colonization by cells had a major influence on initiating and directing cellular activities.…”

Section: Introductionmentioning

confidence: 99%

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Femtosecond laser-induced microstructures on Ti substrates for reduced cell adhesion

et al. 2017

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“…5d are completely wettable by these fluids. This seems to be in accordance with the findings in the references [30,31], which claim that oxidized Ti surfaces are hemocompatible.…”

Section: Discussionsupporting

confidence: 93%

Section: Electron Microscopy Of Cell Covered Surfacesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Femtosecond laser-induced microstructures on Ti substrates for reduced cell adhesion

et al. 2017

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“…Although there are major concerns regarding their use due to their exogenous cytotoxicity, these metallic alloys lack cellular adhesion. However, these may interact with proteins or other living cells leading to a strong immunological reaction that may affect the device functionality [106][107][108]. The unique properties of graphene along with its ability to form conjugates with other molecules due to the availability of a high number of functional groups gives an opportunity to create biocomposites with modified properties.…”

Section: Graphene In Biomedical Implantationmentioning

confidence: 99%

Graphene and graphene oxide as nanomaterials for medicine and biology application

et al. 2018

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Graphene-and graphene oxide-based nanomaterials have gained broad interests in research because of their unique physiochemical properties. The 2D allotropic structure allows it to be used in various biological fields. The biomedical applications of graphene and its composite include its use in gene and small molecular drug delivery. It is further used for biofunctionalization of protein, in anticancer therapy, as an antimicrobial agent for bone and teeth implantation. The biocompatibility of the newly synthesized nanomaterials allows its substantial use in medicine and biology. The current review summarizes the chemical structure and biological application of graphene in various fields.

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“…An improved wettability has been found to promote the interaction between the biological fluid and the implant surface, 22) and also to enhance tissues healing through cell proliferation, adhesion and differentiation. 23,24) Therefore, O-TN specimens (with plasma oxidation) can be expected to have better biocompatibility and osseointegration than TN specimens (without plasma oxidation). Figure 6 displays the XRPD spectra for specimens TN, O-TN(80 W) and O-TN(280 W).…”

Section: )mentioning

confidence: 99%

Enhancement of Biocompatibility on Bioactive Ti-Nb-Based Alloy by High-Density Plasma Modification

Pan

2007

Mater. Trans.

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The formations and characteristics of oxides on the surfaces of the plasma-treated Ti-Nb-Hf alloys were investigated by employing X-ray photoelectron spectroscopy, X-ray powder diffractometer and scanning electron microscopy. Further, the non-treated and plasma-treated specimens were incubated in phosphate-buffered saline (PBS) containing albumin to evaluate their biocompatibility. The results indicate that through O 2 -plasma treatment, the thickness of the oxide layer increases, and the surface roughness improves, exhibiting little protuberances and numerous micropores and cavities on the treated surface. The compositions of the oxide layers in the specimen without O 2 -plasma treatment consist of TiO, Ti 2 O 3 and TiO 2 , and the oxides transform to mainly TiO 2 as the specimen is treated with O 2 -plasma. In addition, the formation of nitrides by allylamine plasma treatment can provide amino-group linkings for the attachment of albumin. Plasma oxidation and polymerization are believed to improve biocompatibility and therefore promote osseointegration.

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Hemocompatibility of titanium oxide films

Cited by 383 publications

References 25 publications

Femtosecond laser-induced microstructures on Ti substrates for reduced cell adhesion

Femtosecond laser-induced microstructures on Ti substrates for reduced cell adhesion

Graphene and graphene oxide as nanomaterials for medicine and biology application

Enhancement of Biocompatibility on Bioactive Ti-Nb-Based Alloy by High-Density Plasma Modification

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