Hemocompatibility challenge of membrane oxygenator for artificial lung technology

TME-triggered copper-coordinated engineered programmable nanogenerators for on-demand cascade-amplifying oxidative stress

“…Hemocompatibility is one of the most important criteria for evaluating the safety of biomaterials. 45 The hemocompatibility of ECH was assessed by co-incubating red blood cells with DI water, PBS, and different concentrations of ECH. Notably, red blood cells incubated with DI water were almost completely ruptured (Fig.…”

Macromolecular Modification Strategies for Biomaterial Surface: Challenges in Fundamental Research and Applications

“…This strategy largely reduces the need for “inertia”. Among the many “bioactive surfaces”, heparin surfaces have been more intensively studied and commercialized. − Heparin covalently immobilized on the surface has been shown to still bind Antithrombin III (AT III) via a specific pentasaccharide sequence, forming an AT III–heparin complex (ATH) that accelerates the inhibition of thrombin and FXa, thereby blocking the pathway of coagulation in vivo (Figure ). …”

The separation membranes in artificial organs

“…16 and Table 2). 58 These microchannels are scattered as branches, resulting in a high surface area for oxygenation (around 75 m 2 ) and a physiologically homogenous blood flow pattern. 17 An adult lung typically contains hundreds of millions of O 2 /CO 2 exchanging alveoli and exchanges 200-250 mL min À1 of O 2 /CO 2 at rest and 6 L min À1 during activity.…”