Hemocompatibility and surface properties of bovine pericardial patches: Effects of gamma sterilization

Rallapalli, Suneel; Liman, Aminu Musa; Guhathakurta, Soma

doi:10.1016/j.cmrp.2016.10.001

Cited by 7 publications

(2 citation statements)

References 16 publications

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“…The increase in the hemolysis ratio is considered due to the irradiation process causing damage to the surface of the biomaterial, which becomes rougher so that it can damage erythrocytes and result in the lysis of hemoglobin. [55] Hemocompatibility characteristics are an important requirement for assessing interactions between drugs or biomaterials that function or are related to the circulatory system. Hemocompatible drug compositions or materials are capable of interacting with blood components without causing clinically significant adverse reactions such as thrombosis, hemolysis, complement activation, or other adverse side effects.…”

Section: Hemolysis Testmentioning

confidence: 99%

In Vitro Hemostatic Activity of Novel Fish Gelatin- Alginate Sponge (FGAS) Prototype

Herliana,

Yusuf,

Laviana

et al. 2024

Preprint

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A hemostatic sponge prototype was successfully synthesized from fish gelatin as an alternative to mammalian gelatin, which was mixed with alginate in certain combinations and double cross-linking of calcium ions and gamma irradiation at a dose of 20 kGy to improve the characteristics and effectiveness of its function as a local hemostatic agent. There was an improvement in the physicochemical and mechanical properties, porosity index, absorption capacity, biodegradation properties, biocompatibility, and hemocompatibility of the FGAS prototypes compared with the pure fish gelatin sponge. Hemostatic activity tests showed that the means of clotting time, prothrombin time, and activated partial thromboplastin time were shorter in the FGAS prototype than in the negative control, and there was no significant difference compared with the commercial gelatin sponge. The hemostatic mechanism of the FGAS prototype combined a passive mechanism as a concentrator factor and an active mechanism through the release of calcium ions as a coagulation factor in the coagulation cascade process.

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Section: Hemolysis Testmentioning

confidence: 99%

In Vitro Hemostatic Activity of Novel Fish Gelatin- Alginate Sponge (FGAS) Prototype

Herliana,

Yusuf,

Laviana

et al. 2024

Preprint

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“…The conformational peak for glycosaminoglycan is between 1250 and 1000 cm À1 range. 25 Whereas, elastin is inferred by carbonyl group ( CO) at amide I and amide II region in the 3400-3220 cm À1 range as C N stretching and, N H bending, and, for collagen, it is present in the range of 1650-1580 cm À1 .…”

Section: Ftirmentioning

confidence: 99%

Evaluation of physicochemical properties of graphene oxide‐decellularized pericardium biohybrid scaffold

Deepak,

Bharat,

R. Babu

2023

J Biomed Mater Res

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The decellularized pericardium has been widely used in cardiac tissue engineering, whereas its clinical applications are limited due to weak mechanical performance, high collagen exposure, and being prone to microbial contamination. In this study, a biohybrid scaffold of the decellularized caprine pericardium (DCP) and graphene oxide (GO) was fabricated by an immersion coating technique. The antimicrobial activity of GO was evaluated against Escherichia coli and showed minimum inhibitory concentration at 125 μg/mL and minimum bactericidal concentration at 250 μg/mL. The presence of GO on the surface of the biohybrid GO‐DCP was confirmed through SEM analysis. The existence of glycosaminoglycan, elastin, and collagen in the DCP and GO‐DCP was inferred from the FTIR spectra. The biocompatibility of GO‐DCP was studied by seeding valvular interstitial cells, and the results show GO coating supports cell adhesion on the serous and fibrous sides of the DCP. Further, the biomechanical response of DCP is unaltered by the presence of GO. In conclusion, GO enhances the biological performance of decellularized pericardium, which can be used in cardiac tissue engineering applications.

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Biocompatible injectable polysaccharide materials for drug delivery

Cadinoiu

Raţă

Atanase

2019

Polysaccharide Carriers for Drug Delivery

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Hemocompatibility and surface properties of bovine pericardial patches: Effects of gamma sterilization

Cited by 7 publications

References 16 publications

In Vitro Hemostatic Activity of Novel Fish Gelatin- Alginate Sponge (FGAS) Prototype

In Vitro Hemostatic Activity of Novel Fish Gelatin- Alginate Sponge (FGAS) Prototype

Evaluation of physicochemical properties of graphene oxide‐decellularized pericardium biohybrid scaffold

Biocompatible injectable polysaccharide materials for drug delivery

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