Hemmung des Tremors durch ?-adrenolytisch wirksame Substanzen

Jacobi, Herbert P.

doi:10.1007/bf00608777

Cited by 7 publications

(3 citation statements)

References 5 publications

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“…It is also not certain whether the inhibition produced by the two peripheral blocking drugs, propranolol, a /3-adrenoceptor and phenoxybenzamine, an a-adrenoceptor antagonist, is a peripheral or central effect. The results obtained with propranolol are in agreement with those of previous authors who found propranolol to be an effective antagonist of tremorine (Agarwal & Bose, 1967;Jacobi, 1967). A peripheral action of propranolol is suggested from results obtained by Marsden, Meadows, Lange & Watson (1967) on man.…”

Section: Discussionsupporting

confidence: 91%

Effects of drugs on tremor and increase in brain acetylcholine produced by oxotremorine in the rat

Cox

Potkonjak

1970

British J Pharmacology

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In rats the effect of drugs on oxotremorine tremor and oxotremorine‐induced increase in brain acetylcholine has been investigated. Reserpine, (±)‐α‐methylmetatyrosine and diethyldithio‐carbamic acid, drugs which have in common the ability to decrease tissue noradrenaline concentration, inhibited oxotremorine tremor without preventing the oxotremorine‐induced increase in brain acetylcholine. (±)‐p‐chlorophenylalanine, a depletor of tissue 5‐hydroxytryptamine, did not inhibit oxotremorine tremor. Phenoxybenzamine and propranolol inhibited oxotremorine tremor, and propranolol was without effect on oxotremorine‐induced increase in brain acetylcholine. The toxicity of oxotremorine was increased by reserpine and phenoxybenzamine. The significance of these findings is discussed with regard to the mode of action of oxotremorine.

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Section: Discussionsupporting

confidence: 91%

Effects of drugs on tremor and increase in brain acetylcholine produced by oxotremorine in the rat

Cox

Potkonjak

1970

British J Pharmacology

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“…Possibly related are propranolol's alleviation of withdrawal tremors (ZILM et aI., 1975), its antianxiety effects (KELLNER et aI., 1974), and its augmentation of ethanol effects (ALKANA et aI., 1976). Propranolol also reportedly blocks the tremors induced by oxotremorine (BRIMBLECOMBE and PINDER, 1972;AGARWAL and BOSE, 1967;JACOBI, 1967;SINHA, 1967, 1968;Cox and POTKONJAK, 1970;WATANABE et aI., 1971).…”

Section: B) Patterns Of Neuronal Discharge and Sensitivity Of Drug Dementioning

confidence: 92%

The Pharmacology of Sedative/Hypnotics, Alcohol, and Anesthetics: Sites and Mechanisms of Action

Smith¹

1977

Drug Addiction I

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“…Propranolol diminishes tremor in patients with Parkinson's disease (Owen & Marsden, 1965;Marsden, Meadows, Lange & Watson, 1967) and inhibits oxotremorine-induced tremor in mice and rats (Jacobi, 1957;Agarwal & Bose, 1967;Cox & Potkonjak, 1970). Some other central effects of oxotremorine, including its analgesic and hypothermic effects are not affected by propranolol (Hermansen, 1968) and it has therefore been suggested that the antitremor action of propranolol is mediated peripherally (Marsden et al, 1967).…”

Section: Introductionmentioning

confidence: 99%

Antioxotremorine Action of Propranolol

Ganguly¹

1976

British J Pharmacology

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I The influence of propranolol on the neuromuscular, tremor-producing and muscarinic effects of oxotremorine was examined. 2 In the isolated rat phrenic nerve-diaphragm preparation the neuromuscular blocking effect of oxotremorine was inhibited by propranolol in a dose-dependent manner. 3 Propranolol intensified the paralytic effect of tubocurarine in the rat diaphragm and prevented antagonism of tubocurarine paralysis by tetraethylammonium. 4 Propranolol was devoid of any curare-like effect in the isolated rectus abdominis muscle of the frog. SVasodepressor responses to oxotremorine in rats and spasmogenic responses to oxotremorine in guinea-pig ileum were not antagonized by propranolol. 6 A dose-dependent antagonism of oxotremorine-induced tremor in mice was observed after pretreatment with propranolol and it is suggested that this effect is due to an antagonism of a presynaptic effect of oxotremorine at skeletal neuromuscular junctions.

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Hemmung des Tremors durch ?-adrenolytisch wirksame Substanzen

Cited by 7 publications

References 5 publications

Effects of drugs on tremor and increase in brain acetylcholine produced by oxotremorine in the rat

Effects of drugs on tremor and increase in brain acetylcholine produced by oxotremorine in the rat

The Pharmacology of Sedative/Hypnotics, Alcohol, and Anesthetics: Sites and Mechanisms of Action

Antioxotremorine Action of Propranolol

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