Hemmung der Xanthinoxydase durch Isatin, Ninhydrin und Alloxan

Bruns, Friedrich

doi:10.1007/bf00643286

Cited by 7 publications

(7 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Befunde über die Wirkung des Isatins auf ein Flavinenzym, die Xanlhinoxydase, sprechen dafür, daß der Hemmungseffekt über eine Reaktion mit dem Fermenlprotein zustande kommt (Bruns, 1954 …”

Section: Methodenunclassified

“…Nach den Ergeb nissen chemischer und biochemischer Studien mit Isatin (Langenbeck, 1927;Abderhalden, 1938;Bruns, 1954), aber auch im Zu sammenhang mit der Frage nach den Beziehungen zwischen chemischer Konstitution und pharmakologischer Wirkung er schien es uns von einigem Interesse, den Effekten des 2.3-Dioxoindols nachzugehen und sie mit denen des Grundkörpers zu verglei chen. In der vorliegenden Arbeit wird u. a. über einige zentrale Wirkungen beider Stoffe berichtet.…”

unclassified

See 1 more Smart Citation

Vergleichende pharmakologische Studien mit Indol und Isatin

Müller¹

1962

Pharmacology

View full text Add to dashboard Cite

Section: Methodenunclassified

unclassified

Vergleichende pharmakologische Studien mit Indol und Isatin

Müller¹

1962

Pharmacology

View full text Add to dashboard Cite

“…Isatin was reported as one the substances with a vital role as signalling substance between microorganisms for production of antibiotics. In addition, it is active as inhibitor of Xanthine-oxidase of milk [275] and monoamine oxidase [276] . Isatin is known as fungal pigment from a mutant of Schizophyllum commune [277] .…”

Section: Marine Streptomyces Sp B7874mentioning

confidence: 99%

“…Antibacterial and antifungal activities of the isolated compounds (267, 269, 271~273, 275 and 276) were semi-quantitatively determined using the agar diffusion method with 9 mm paper discs and 20 µg /disk. Cinerubin A (275) exhibited activity against all the tested microorganisms, while cinerubin B (273) showed only activity against Staphylococcus aureus (Table 81). [152,414,415] , and bafilomycin C 1 -amide (116).…”

Section: Cinerubin Bmentioning

confidence: 99%

A new 16-membered tetraene macrolide JBIR-100 from a newly identified Streptomyces species

Ueda¹,

Hashimoto²,

Yamamura³

et al. 2011

J Antibiot

View full text Add to dashboard Cite

Section: Marine Streptomyces Sp B7874mentioning

confidence: 99%

Nafisamycin, Cyclisation Product of a New Enediyne Precursor, Highly Cytotoxic Mansouramycins, Karamomycins Possessing a Novel Heterocyclic Skeleton and Further Unusual Secondary Metabolites from Terrestrial and Marine Bacteria.

Mahmoud¹

View full text Add to dashboard Cite

sources of bioactive constituents, as most medicinal plants (~97%) have been totally investigated. So, many other natural sources were being taken into consideration, especially those located in marine habitats e.g. soft corals, sponges, jellyfishes, algae, and microorganisms. Microorganisms are living symbiotically or located in sediments and represent a huge source of diverse bioactive secondary metabolites. Such diversity increases the possibility of structural novelty as well as bioactivity.Penicillin (1), one of the first antibiotics from microorganisms, was discovered in 1928 by Fleming, showing a bactericidal activity against the Staphylococcus sp.For this great discovery, Fleming, Chian and Florey were honoured with the Nobel Prize in 1945 [7] . Since the discovery of penicillin (1) and mycophenolic acid (2) before [8] , microorganisms, especially bacteria, played an essential role in the production of antibiotics and other drugs for the treatment of current diseases [9, 10] . 7The systematic investigations of marine environment as sources of novel biologically active agents began intensively in the mid 1970s. Among the phyla in the oceans, bacteria, fungi, algae, sponges, coelenterates, sea hares, bryozoans, tunicates and nudibranchs have been studied [28,29] . There is, however, a continual increasing of the reported new compounds from marine sources since 1965 (Figure 1). Sponges followed by coelenterates were the most studied marine organisms. Since that time, 13Didemnin B (13), a depsipeptide, was isolated from the Caribbean tunicateTrididemnum solidum [34] , inhibiting the synthesis of RNA, DNA and proteins in various cancer cell lines. It shows anti-viral and immunosuppressive activities as well as being an effective agent in treatment of leukaemia and melanoma. However, due to its toxicity, it was withdrawn from phase II clinical trials [35,36] .Thiocoraline ( 14), a novel depsipeptide was isolated (1997) from the mycelial extract of the bacterium Micromonospora marina, associated with a marine soft coral in the Indian Ocean. Thiocoraline (14) showed potent cytotoxic activity at a nanomolar concentration against several tumor cell lines. It inhibits DNA polymerase [37,38] . It is currently in preclinical phase by PharmaMar.

show abstract

Hemmung der Xanthinoxydase durch Isatin, Ninhydrin und Alloxan

Cited by 7 publications

References 11 publications

Vergleichende pharmakologische Studien mit Indol und Isatin

Vergleichende pharmakologische Studien mit Indol und Isatin

A new 16-membered tetraene macrolide JBIR-100 from a newly identified Streptomyces species

Nafisamycin, Cyclisation Product of a New Enediyne Precursor, Highly Cytotoxic Mansouramycins, Karamomycins Possessing a Novel Heterocyclic Skeleton and Further Unusual Secondary Metabolites from Terrestrial and Marine Bacteria.

Contact Info

Product

Resources

About