Hemispherotomy for late post-traumatic super-refractory status epilepticus in an adult

Nayak, Raghavendra; Mathew, Vivek; Rajgopal, Ramanan; Raju, Krishnaprabhu

doi:10.1016/j.ebcr.2017.08.004

Cited by 3 publications

(1 citation statement)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Given the relatively low incidence of SRSE, clinical trials are quite challenging from a feasibility standpoint. Accordingly, although there are no randomized controlled trials supporting any specific treatment modality, there are abundant contemporary case reports and case series suggesting effectiveness of multiple therapies including ketamine [4] , ketogenic diet therapy [5] , [6] , electroconvulsive therapy [7] , thalamic deep brain stimulation [8] , repetitive transcranial magnetic stimulation [9] , surgical resection (even hemispherectomy) [10] , [11] , immunotherapy (i.e. corticosteroids) [12] , and most recently, allopregnanolone [13] , [14] , [15] .…”

Section: Introductionmentioning

confidence: 99%

Successful use of pure cannabidiol for the treatment of super-refractory status epilepticus

Rajaraman

Sankar

Hussain

2018

Epilepsy & Behavior Case Reports

View full text Add to dashboard Cite

We present the case of a child with long-standing, super-refractory status epilepticus (SRSE) who manifested prompt and complete resolution of SRSE upon exposure to pure cannabidiol. SRSE emerged in the context of remote suspected encephalitis with previously well-controlled epilepsy. We discuss the extent to which response may be specifically attributed to cannabidiol, with consideration and discussion of multiple potential drug–drug interactions. Based on this case, we propose that adjunctive cannabidiol be considered in the treatment of SRSE.

show abstract

Section: Introductionmentioning

confidence: 99%

Successful use of pure cannabidiol for the treatment of super-refractory status epilepticus

Rajaraman

Sankar

Hussain

2018

Epilepsy & Behavior Case Reports

View full text Add to dashboard Cite

show abstract

Combined Responsive Neurostimulation and Focal Resection for Super Refractory Status Epilepticus: A Systematic Review and Illustrative Case Report

Mamaril-Davis¹,

Vessell²,

Ball³

et al. 2022

World Neurosurgery

View full text Add to dashboard Cite

Comparative Analysis of Hemispherotomy in Adults versus Children- A Prospective Observational Series

Bajaj,

Chandra,

Ramanujam

et al. 2024

Neurology India

View full text Add to dashboard Cite

Background: Hemispherotomy (HS) is an effective treatment for unilateral hemispheric onset epilepsy. There are few publications for HS in adults, and there is no series comparing adults and pediatric patients of HS. Objective: To compare the hemispherotomies done in adult patients with pediatric ones in terms of efficacy and safety. Methods: Data was prospectively collected for HS patients (up to 18 years and more) from Aug 2014 to Aug 2018. Comparison between the groups was made for seizure onset, duration of epilepsy, frequency of seizures, number of drugs, intraoperative blood loss, postoperative seizure control, postoperative stay, postoperative motor functions, and preoperative and postoperative intelligence quotient. Follow-up was one year. Results: A total of 61 pediatric and 11 adults underwent HS. The seizure onset was earlier in children, and the duration of epilepsy was longer in adults. The frequency of seizures per day was more in children being 14.62 ± 26.34 in children, and 7.71 ± 5.21 per day in adults (P - 0.49). The mean number of drugs was similar in the preoperative and postoperative periods in both. Class I seizure outcome was similar in both the groups being 85.24% in children and 90.9% in adults (P - 0.56). Blood loss, postoperative stay, was similar in both the groups. No patient had a new permanent motor deficit. Power worsened transiently in 1 pediatric patient and in 4 adult patients. The visual word reading and object naming improved in both the groups (no intergroup difference), and IQ remained the same in both groups. One adult patient had meningitis, and another had hydrocephalus requiring shunt placement. Conclusion: Hemispherotomy is a safe and effective procedure in adults as in children in appropriately selected patients.

show abstract

Hemispherotomy for late post-traumatic super-refractory status epilepticus in an adult

Cited by 3 publications

References 14 publications

Successful use of pure cannabidiol for the treatment of super-refractory status epilepticus

Successful use of pure cannabidiol for the treatment of super-refractory status epilepticus

Combined Responsive Neurostimulation and Focal Resection for Super Refractory Status Epilepticus: A Systematic Review and Illustrative Case Report

Comparative Analysis of Hemispherotomy in Adults versus Children- A Prospective Observational Series

Contact Info

Product

Resources

About