Hemispheric surgery for refractory epilepsy in children and adolescents: Outcome regarding seizures, motor skills and adaptive function

Hamad, Ana Paula Andrade; Caboclo, Luís Otávio Sales Ferreira; Centeno, Ricardo Silva; Costa, Lívia Vianez; Ladeia-Frota, Carol; Carrete, Henrique; Gómez, Nicolás Garófalo; Marinho, Murilo Martinez; Yacubian, Elza Márcia Targas; Sakamoto, Américo Ceiki

doi:10.1016/j.seizure.2013.06.001

Cited by 22 publications

(13 citation statements)

References 25 publications

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“…Thirteen intervention studies of children with conditions/clinical descriptions other than CP tracked baseline and postintervention GMFCS levels, and reported the number of participants who changed levels and the number of levels changed (e.g. two levels if reclassified from level IV to level II).…”

Section: Resultsmentioning

confidence: 99%

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Should the Gross Motor Function Classification System be used for children who do not have cerebral palsy?

Towns

Rosenbaum

Palisano

et al. 2017

Develop Med Child Neuro

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Section: Resultsmentioning

confidence: 99%

“…Among the 118 papers, 76 did not mention that the GMFCS was developed specifically for use with children with CP or discuss its measurement properties . Twenty noted that the GMFCS was created for children with CP but did not justify its application to their condition/clinical description .…”

Section: Resultsmentioning

confidence: 99%

Should the Gross Motor Function Classification System be used for children who do not have cerebral palsy?

Towns

Rosenbaum

Palisano

et al. 2017

Develop Med Child Neuro

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“…To date, unsurprisingly given their importance, most investigations of post-resection plasticity have been concerned with the changes in intelligence (Vargha-Khadem and Polkey, 1992), memory (Meekes et al, 2013; Skirrow et al, 2015; Stretton et al, 2014), language (De Koning et al, 2009), or motor function (Bernasconi et al, 2000; Buckley et al, 2014; Hamad et al, 2013; Mullin et al, 2016). While such investigations offer rich descriptions of the neural and behavioral changes, many questions remain, including, what exact underlying mechanisms support the pattern of reorganization, whether reorganization follows a similar trajectory independent of etiology (e.g.…”

Section: Introductionmentioning

confidence: 99%

Functional outcomes following lesions in visual cortex: Implications for plasticity of high-level vision

Behrmann

2017

Neuropsychologia

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Understanding the nature and extent of neural plasticity in humans remains a key challenge for neuroscience. Importantly, however, a precise characterization of plasticity and its underlying mechanism has the potential to enable new approaches for enhancing reorganization of cortical function. Investigations of the impairment and subsequent recovery of cognitive and perceptual functions following early-onset cortical lesions in humans provide a unique opportunity to elucidate how the brain changes, adapts, and reorganizes. Specifically, here, we focus on restitution of visual function, and we review the findings on plasticity and re-organization of the ventral occipital temporal cortex (VOTC) in published reports of 46 patients with a lesion to or resection of the visual cortex early in life. Findings reveal that a lesion to the VOTC results in a deficit that affects the visual recognition of more than one category of stimuli (faces, objects and words). In addition, the majority of pediatric patients show limited recovery over time, especially those in whom deficits in low-level vision also persist. Last, given that neither the equipotentiality nor the modularity view on plasticity was clearly supported, we suggest some intermediate possibilities in which some plasticity may be evident but that this might depend on the area that was affected, its maturational trajectory as well as its structural and functional connectivity constraints. Finally, we offer suggestions for future research that can elucidate plasticity further.

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“…In the literature, the seizure outcome after hemispherectomy in children varies from 52 to 80% upon follow-up 1 year after surgery, and remains stable beyond 5 years at 58–63% [ 1 – 5 ]. The most common cause of surgical failure after hemispherectomy is incomplete disconnection [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Usefulness of intraoperative insular electrocorticography in modified functional hemispherectomy

Kim

Seo²,

Baumgartner³

et al. 2017

BMC Neurol

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BackgroundThe insular cortex is not routinely removed in modified functional hemispherectomy due to the risk of injury to the main arteries and to deep structures. Our study evaluates the safety and usefulness of applying intraoperative electrocorticography (ECoG) on the insular during the hemispherectomy.MethodsWe included all patients who underwent insular ECoG during a modified functional hemispherectomy from 2012 to 2015. After the surgery, the decision for further resection of the insular cortex was made based on the presence of electrographic seizures on ECoG.ResultsThe study included 19 patients (age, 6.4 ± 4.7 years, mean ± standard deviation). Electrographic seizures were identified in 5 patients (26.3%). Sixteen of the 19 patients (84.2%) became seizure-free with a follow-up duration of 3.1 ± 0.6 years and no vascular complication occurred.ConclusionsIntraoperative insular ECoG monitoring can be performed safely while providing a tailored approach for insular resection during modified hemispherectomy.

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Hemispheric surgery for refractory epilepsy in children and adolescents: Outcome regarding seizures, motor skills and adaptive function

Cited by 22 publications

References 25 publications

Should the Gross Motor Function Classification System be used for children who do not have cerebral palsy?

Should the Gross Motor Function Classification System be used for children who do not have cerebral palsy?

Functional outcomes following lesions in visual cortex: Implications for plasticity of high-level vision

Usefulness of intraoperative insular electrocorticography in modified functional hemispherectomy

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