Hemispheric imbalances in schizophrenia

Gruzelier, John

doi:10.1016/0167-8760(84)90043-6

Cited by 140 publications

(28 citation statements)

References 50 publications

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“…In this study, left-sided coherence abnormalities did not become obvious when we analyzed EEGs recorded in the resting condition, also suggesting the clinical utility of this technique in the evaluation of brain dysfunction [8,26]. There have been electrophysiological and neuroimaging findings suggesting an association between positive symptoms and left-sided dysfunction in schizo-phrenia [40][41][42]. In fact, Norman et al [43] found that reality distortion symptoms (i.e., hallucinations and delusions) had a significant relationship with left fronto-temporal coherence abnormalities in their schizophrenic patients.…”

Section: Discussionmentioning

confidence: 78%

Aberrant Functional Organization in Schizophrenia: Analysis of EEG Coherence during Rest and Photic Stimulation in Drug-Naive Patients

Wada

Nanbu²,

Kikuchi³

et al. 1998

Neuropsychobiology

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EEG coherence provides a measure of functional correlations between two EEG signals. The present study was conducted to examine intrahemispheric EEG coherence at rest and during photic stimulation (PS) in 18 drug-naive patients with paranoid schizophrenia and 30 control subjects. Compared with the controls, the schizophrenic patients had significantly higher intrahemispheric coherence of the resting EEG for the delta band, although no significant group differences were found for other frequency bands. EEG analysis during PS showed that the patients also had significantly higher EEG coherence over the left posterior regions. In this study, we also examined the changes in intrahemispheric coherence from rest to the stimulus condition (i.e., PS-related coherence reactivity); the patients were found to show significantly smaller changes, with significant group differences being also confined to the posterior regions in the left hemisphere. These findings provide evidence that schizophrenic patients have abnormal EEG coherence in both resting and stimulus conditions and suggest more diffuse, undifferentiated functional organization within hemispheres. In addition, diminished coherence reactivity suggests a failure of PS-related functional reorganization in schizophrenia.

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Section: Discussionmentioning

confidence: 78%

Aberrant Functional Organization in Schizophrenia: Analysis of EEG Coherence during Rest and Photic Stimulation in Drug-Naive Patients

Wada

Nanbu²,

Kikuchi³

et al. 1998

Neuropsychobiology

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“…The assessment of bilateral electrodermal activity has been useful in assessing and treating attention-deficit/hyperactivity and learning disorders (Mangina and Beuzeron-Mangina, 2004) and in diagnosing different schizophrenic syndromes (Gruzelier, 1984). On the other hand lesions in left hemisphere were associated with decreases in sexual desire, whereas damages in right hemisphere were related to dysfunctional hypersexuality (Braun et al, 2003), and both diminished EEG activation in right hemisphere sites and increased EEG activation in left hemisphere sites in response to visual erotic stimulation was associated with psychogenic impotence (Cohen et al, 1985) and male fetishistic and sadomasochistic tendencies (Waisman et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

Skin conductance responses to visual sexual stimuli

Costa

Esteves

2008

International Journal of Psychophysiology

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“…1979), using a variety of psychophysiological and behavioural techniques, has supported the belief that lateralized abnormalities are present in schizophrenia. His recent research (Gruzelier, 1984) suggests that these may take the form of over-activation of either the left or the right hemisphere depending on the arousal level of the patient or the subcategory of the disease that he or she manifests.Dichotic listening studies using linguistic stimuli have generally shown normal patterns of laterality in schizophrenia (a right ear/left hemisphere superiority) but, in some studies at least, certain subgroups of schizophrenics have shown larger ear asymmetries than normals (Lerner ef al., …”

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confidence: 98%

Interhemispheric coordination and focused attention in chronic and acute schizophrenia

Green¹

1985

British J Clinic Psychol

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Groups of chronic and acute schizophrenics, together with controls, were given a story comprehension task where material was presented either binaurally or monaurally. A significant right ear advantage was found in the scores of the acute patients but not in those of chronics or controls. Similarly, acutes, in contrast to all other subjects, demonstrated a binaural performance decrement relative to their preferred ear in the monaural condition. A second experiment showed that acute schizophrenics, in contrast to an earlier finding with chronics, were no better at detecting targets in dichotically presented word lists when the targets occurred in one ear only than when they could occur in either ear. It is suggested that this inability to focus attention on one ear, in the presence of competing stimulation to the other, was responsible for the story comprehension result.

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Hemispheric imbalances in schizophrenia

Cited by 140 publications

References 50 publications

Aberrant Functional Organization in Schizophrenia: Analysis of EEG Coherence during Rest and Photic Stimulation in Drug-Naive Patients

Aberrant Functional Organization in Schizophrenia: Analysis of EEG Coherence during Rest and Photic Stimulation in Drug-Naive Patients

Skin conductance responses to visual sexual stimuli

Interhemispheric coordination and focused attention in chronic and acute schizophrenia

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