Hemispheric coupling between structural and functional asymmetries in clinically asymptomatic carotid stenosis with cognitive impairment

Fan, Chenhong; Xu, Dan; Mei, Hao; Zhong, Xiaoli; Ren, Jinxia; Ma, Jiaojiao; Ruan, Zhao; Lv, Jinfeng; Liu, Xitong; Wang, Huan; Gao, Lei; Xu, Haibo

doi:10.1007/s11682-023-00823-0

Cited by 1 publication

(1 citation statement)

References 61 publications

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“…Then, we investigated the asymmetric microstructure-function coupling. Structural brain asymmetry is linked to behavioral differences such as variability in language skills (Fan et al, 2023; Powell et al, 2006; Qi et al, 2019) and mental health (Kong et al, 2022) such as autism (Postema et al, 2019; Sha et al, 2022), attention-deficit/hyperactivity disorder (Postema et al, 2021), schizophrenia (Schijven et al, 2023), and substance dependence (Cao et al, 2021). Finally, based on the healthy HCP sample, we investigated the associations between microstructural asymmetry and individual differences in language skills, as well as its potential relevance to mental health traits including depression, anxiety, somatic, avoidant, ADHD, and antisocial phenotypes.…”

Section: Mainmentioning

confidence: 99%

Microstructural asymmetry in the human cortex

Wan,

Saberi,

Paquola

et al. 2024

Preprint

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While macroscale brain asymmetry and its relevance for human cognitive function have been consistently shown, the underlying neurobiological signatures remain an open question. Here, we probe layer-specific microstructural asymmetry of the human cortex using intensity profiles from post-mortem cytoarchitecture. An anterior-posterior cortical pattern of left-right asymmetry was found, varying across cortical layers. A similar anterior-posterior pattern was observed using in vivo microstructural imaging, with in vivo asymmetry showing the strongest similarity with layer III. Microstructural asymmetry varied as a function of age and sex and was found to be heritable. Moreover, asymmetry in microstructure corresponded to asymmetry of intrinsic function, in particular in sensory areas. Last, probing the behavioral relevance, we found differential association of language and markers of mental health with asymmetry, illustrating a functional divergence between inferior-superior and anterior-posterior microstructural axes anchored in microstructural development. Our study highlights the layer-based patterning of microstructural asymmetry of the human cortex and its functional relevance.

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