Hemispheric asymmetries in cerebral cortical networks

Hutsler, Jeffrey J.; Galuske, Ralf A. W.

doi:10.1016/s0166-2236(03)00198-x

Cited by 216 publications

(128 citation statements)

References 60 publications

Supporting

Mentioning

119

Contrasting

Unclassified

Order By: Relevance

“…While smaller RFs are hypothesized to represent quick, consolidated processing circuits, larger RFs are thought to process broader categories of information obtained form disparate sources (Kosslyn, 1991). There is all ready some evidence that semantic receptive fields are larger in the RH than the LH (Hutsler and Galuske, 2003). If the receptive fields of neurons in the left and right components of the MNS follow this pattern, it is reasonable to assume that the right hemisphere would be better able to compute appropriate responses to ongoing actions in joint-action scenarios where one must take into account the current actions of multiple actors.…”

Section: Joint-action Dependency and The Right Hemispherementioning

confidence: 99%

Anatomical substrates of cooperative joint-action in a continuous motor task: Virtual lifting and balancing

et al. 2008

View full text Add to dashboard Cite

An emerging branch of social cognitive neuroscience attempts to unravel the critical cognitive mechanisms that enable humans to engage in joint action. In the current experiment, differences in brain activity in participants engaging in solitary action and joint action were identified using whole brain fMRI while participants performed a virtual barbalancing task either alone (S), or with the help of a partner in each of two separate joint-action conditions (isomorphic [J i ] and non-isomorphic [J n ]). Compared to the performing the task alone, BOLD signal was found to be stronger in both joint-action conditions at specific sites in the human mirror system (MNS). This activation pattern may reflect the demand on participants to simulate the actions of others, integrate their own actions with those of their partners, and compute appropriate responses. Increasing inter-dependence (complementarity) of movements being generated by cooperating individuals (J n N J i N S) was found to correlate with BOLD signal in the right anterior node of the MNS (pars opercularis), and the area around the right temporoparietal junction (TPJ). These data are relevant to current debates concerning the role of right IFG in complementary action, as well as evolving theories of joint action.

show abstract

Section: Joint-action Dependency and The Right Hemispherementioning

confidence: 99%

Anatomical substrates of cooperative joint-action in a continuous motor task: Virtual lifting and balancing

et al. 2008

View full text Add to dashboard Cite

show abstract

“…In the normal human brain, there are significant differences in minicolumn organization between the left and right sides [for review, see Hutsler and Galuske, 2003]. These differences suggest that alterations in minicolumn organization-in autism-may have a profound impact on hemispheric specialization and functions that dependent on hemispheric specialization (such as language).…”

Section: Brain Serotonin In Autistic Childrenmentioning

confidence: 99%

Serotonin in autism and pediatric epilepsies

Chugani

2004

Ment. Retard. Dev. Disabil. Res. Rev.

View full text Add to dashboard Cite

Serotonergic abnormalities have been reported in both autism and epilepsy. This association may provide insights into underlying mechanisms of these disorders because serotonin plays an important neurotrophic role during brain development-and there is evidence for abnormal cortical development in both autism and some forms of epilepsy. This review explores the hypothesis that an early disturbance in the serotonin system affects cortical development and the development of thalamocortical innervation, and is a potential mechanism, common to autism and pediatric epilepsies associated with cortical dysplasia. An argument is made that cortical malformation leads to abnormalities of thalamocortical connectivity, and that serotonin plays a critical role in this process. Finally, a role for altered metabolism of the serotonin precursur, tryptophan, in both epilepsy and autism is discussed. Key Words: serotonin; autism; epilepsy; tryptophan; cortical development; kynurenine E pilepsy is more common among autistic children than in the general population; conversely, autism (or milder pervasive developmental disorders) is more common in epileptic children than in the general population. There is evidence for abnormalities of the neurotransmitter serotonin in both epilepsy and autism. The role of serotonin in brain development is briefly reviewed here and then the evidence considered for a role of an altered serotonin system in these developmental disorders. We hypothesize that serotonergic abnormalities during prenatal and early postnatal development may lead to changes in thalamocortical connectivity, which results in a predisposition for autism and epilepsy. In addition, we discuss the involvement of aberrant metabolism of tryptophan-the metabolic precursor of serotonin-as a potential mechanism for alterations in serotonin availability.

show abstract

“…In most healthy right handers, the left superior temporal lobe, which includes Heschl's gyrus (HG) and planum temporale (PT), is larger than the right hemisphere counterpart (Galaburda and Geschwind, 1981;Morosan et al, 2001;Zatorre et al, 2002;Chance et al, 2006), and differs from the right hemisphere in microanatomical structure at the columnar level (Hutsler and Galuske, 2003). Crow and colleagues (Crow et al, 1989;Crow, 1997) proposed that schizophrenia (SZ) results from a failure of normal cerebral lateralization and that this failure is genetically determined.…”

Section: Introductionmentioning

confidence: 99%

Reduced Laterality as a Trait Marker ofSchizophrenia—Evidence from Structural and Functional Neuroimaging

Oertel¹,

Knöchel²,

Rotarska-Jagiela³

et al. 2010

J. Neurosci.

119

View full text Add to dashboard Cite

Laterality is a characteristic principle of the organization of the brain systems for language, and reduced hemispheric asymmetry has been considered a risk factor for schizophrenia. Here we sought support for the risk factor hypothesis by investigating whether reduced asymmetry of temporal lobe structure and function is also present in unaffected relatives. Sixteen schizophrenia patients, 16 age-matched first-degree relatives, and 15 healthy controls underwent high-resolution three-dimensional anatomical imaging and functional magnetic resonance imaging during auditory stimulation. Both the overall auditory cortex and planum temporale volumes and the lateralization to the left hemisphere were markedly reduced in patients. The decrease of lateralization correlated with increased severity of symptoms. In addition, both the overall functional activation in response to auditory stimulation and its asymmetry were reduced in the patients. Relatives had intermediate values between patients and controls on both structural and functional measures. This study provides added support for the idea that reduced hemispheric asymmetry is a biological risk factor for schizophrenia.

show abstract

Hemispheric asymmetries in cerebral cortical networks

Cited by 216 publications

References 60 publications

Anatomical substrates of cooperative joint-action in a continuous motor task: Virtual lifting and balancing

Anatomical substrates of cooperative joint-action in a continuous motor task: Virtual lifting and balancing

Serotonin in autism and pediatric epilepsies

Reduced Laterality as a Trait Marker ofSchizophrenia—Evidence from Structural and Functional Neuroimaging

Contact Info

Product

Resources

About