Hemisphere-specific effects on serotonin but not dopamine innervation in the nucleus accumbens of gerbils caused by isolated rearing and a single early methamphetamine challenge

Lesting, Jörg; Neddens, Joerg; Busche, Andrea; Teuchert-Noodt, Gertraud

doi:10.1016/j.brainres.2004.12.005

Cited by 16 publications

(14 citation statements)

References 65 publications

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“…The maturation of ascending dopaminergic projections in cortical areas, as well as the nucleus accumbens, is an ongoing process that continues into adulthood (Kalsbeek et al, 1988). Maturation of mesocorticolimbic circuitry is critical for the appropriate formation of descending cortical projections, and maladaptations within this circuitry have been experimentally linked to the expression of psychotic-like behaviors, as well as early onset drug taking (Laviola et al, 1999, 2001; Lesting et al, 2005). Also of note is a “pruning” of D1 dopamine receptors at the onset of periadolescence (Teicher et al, 1995).…”

Section: Neurobiological Characteristics Therapeutics and Drug Abusementioning

confidence: 99%

Social stress, therapeutics and drug abuse: Preclinical models of escalated and depressed intake

Miczek

Yap

Covington

2008

Pharmacology & Therapeutics

292

252

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The impact of ostensibly aversive social stresses on triggering, amplifying and prolonging intensely rewarding drug taking is an apparent contradiction in need of resolution. Social stress encompasses various types of significant life events ranging from maternal separation stress, brief episodes of social confrontations in adolescence and adulthood, to continuous subordination stress, each with its own behavioral and physiological profile. The neural circuit comprising the VTA–accumbens–PFC–amygdala is activated by brief episodes of social stress, which is critical for the DA-mediated behavioral sensitization and increased stimulant consumption. A second neural circuit comprising the raphe–PFC–hippocampus is activated by continuous subordination stress and other types of uncontrollable stress. In terms of the development of therapeutics, brief maternal separation stress has proven useful in characterizing compounds acting on subtypes of GABA, glutamate, serotonin and opioid receptors with anxiolytic potential. While large increases in alcohol and cocaine intake during adulthood have been seen after prolonged maternal separation experiences during the first two weeks of rodent life, these effects may be modulated by additional yet to be identified factors. Brief episodes of defeat stress can engender behavioral sensitization that is relevant to escalated and prolonged self-administration of stimulants and possibly opioids, whereas continuous subordination stress leads to anhedonia-like effects. Understanding the intracellular cascade of events for the transition from episodic to continuous social stress in infancy and adulthood may provide insight into the modulation of basic reward processes that are critical for addictive and affective disorders.

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Section: Neurobiological Characteristics Therapeutics and Drug Abusementioning

confidence: 99%

Social stress, therapeutics and drug abuse: Preclinical models of escalated and depressed intake

Miczek

Yap

Covington

2008

Pharmacology & Therapeutics

292

252

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“…This finding is consistent with data from male C57Bl6 mice, in which isolation inhibits the extinction but not formation of fear memories (Pibiri et al 2008). Intriguingly, housing under semi-natural, enriched conditions appears to mediate at least some of the developmental effects of social isolation on the NAc (Lesting et al 2005). …”

Section: Effects Of Social Contextmentioning

confidence: 99%

Stress responses and the mesolimbic dopamine system: Social contexts and sex differences

Trainor

2011

Hormones and Behavior

119

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Organisms react to threats with a variety of behavioral, hormonal, and neurobiological responses. The study of biological responses to stress has historically focused on the hypothalamic-pituitary-adrenal axis, but other systems such as the mesolimbic dopamine system are involved. Behavioral neuroendocrinologists have long recognized the importance of the mesolimbic dopamine system in mediating the effects of hormones on species specific behavior, especially aspects of reproductive behavior. There has been less focus on the role of this system in the context of stress, perhaps due to extensive data outlining its importance in reward or approach-based contexts. However, there is steadily growing evidence that the mesolimbic dopamine neurons have critical effects on behavioral responses to stress. Most of these data have been collected from experiments using a small number of animal model species under a limited set of contexts. This approach has led to important discoveries, but evidence is accumulating that mesolimbic dopamine responses are context dependent. Thus, focusing on a limited number of species under a narrow set of controlled conditions constrains our understanding of how the mesolimbic dopamine system regulates behavior in response to stress. Both affiliative and antagonistic social interactions have important effects on mesolimbic dopamine function, and there is preliminary evidence for sex differences as well. This review will highlight the benefits of expanding this approach, and focus on how social contexts and sex differences can impact mesolimbic dopamine stress responses.

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“…In general, brain weights of rodents reared under deprived conditions are lower than brain weights of those reared under enriched conditions (Henderson, 1976;Iso et al, 2007;Rosenzweig & Bennett, 1969). Deprived-rearing conditions led to severe impairments in the prefrontal cortex of gerbils Brummelte, Neddens, & Teuchert-Noodt, 2007;Neddens, Brandenburg, Teuchert-Noodt, & Dawirs, 2001;Winterfeld, Teuchert-Noodt, & Dawirs, 1998;Witte, Brummelte, & Teuchert-Noodt, 2007) and rats (Bloomfield et al, 2008;Leng, Feldon, & Ferger, 2004;Melendez, Gregory, Bardo, & Kalivas, 2004;Pascual, Zamora-Leon, CatalanAhumeda, & Valero-Cabre, 2007) as well as in regions involved in emotional and motivational processes, including exploration (Bowling, Rowlett, & Bardo, 1993;Busche, Bagorda, Lehmann, Neddens, & TeuchertNoodt, 2006;Busche, Neddens, Dinter, Dawirs, & Teuchert-Noodt, 2002;Busche, Polaschek, Lesting, Neddens, & Teuchert-Noodt, 2004;Heidbreder et al, 2000;Lehmann, Lesting, Polaschek, & Teuchert-Noodt, 2003;Lesting, Neddens, Busche, & Teuchert-Noodt, 2005). It further led to decreased neurogenesis in the dentate gyrus of C57 BL/6 mice (Iso et al, 2007), decreased cell survival in the dentate gyrus of rats (Nilsson, Perfilieva, Johannson, Orwar, & Eriksson, 1999), decreased levels of neurotrophin protein (Zhu et al, 2006), decreased levels of pregnenolone and progesterone in the rat hippocampus (Serra et al, 2000), and decelerated development of the visual system upon delayed eye opening in mice (Cancedda et al, 2004).…”

Section: Introductionmentioning

confidence: 96%

“…Deprived-rearing conditions also affect brain systems implicated in the generation (Graybiel, 2000) as well as inhibitory control of motor activity (Doya, 2000), that is, the basal ganglia and specifically the striatum, in various rodent species (reviewed in Würbel, 2001). Postnatal deprivation influences the ontogeny of dopamine and serotonin in the striatum of gerbils (Lehmann et al, 2003;Lehmann, Teuchert-Noodt, & Dawirs, 2002;Lesting et al, 2005) and social isolation affects dopamine and 5-HT innervation in the striatum of rats (Jones, Hernandez, Kendall, Marsden, & Robbins, 1992). Neural impairment is therefore coupled with specific reductions of learning abilities (Henderson, 1976;Renner & Rosenzweig, 1987;reviewed in Roy, Belzung, Delarue & Chapillon, 2001) such as reduced performance during orientation in a plus maze (Friske & Gammie, 2005), in a complex radial maze test (Janus, Koperwas, Janus, & Roder, 1995), in a Hebb-Williams maze (Smith, 1972), impairments in the inhibitory control of attentional selection (Würbel, 2001), delayed alternation (Winterfeld et al, 1998), water maze learning of mice Iso et al, 2007) and rats (Leggio et al, 2005), forced spatial working memory tasks in the T-maze in rats (Melendez et al, 2004), and reversal learning (Schrijver, Pallier, Brown, & Würbel, 2004).…”

Section: Introductionmentioning

confidence: 99%

Effects of postweaning social and physical deprivation on locomotor activity patterns and explorative behavior in female CD‐1 mice

Haupt

Schaefers

2010

Developmental Psychobiology

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Social and physical deprivation during adolescence has detrimental consequences for brain maturation and cognitive functions. To test the hypothesis that social and physical deprivation during mouse adolescence would disrupt activity and exploration behavior, we exposed mice either to deprived or enriched rearing (postnatal days 21-60) and assessed activity and exploration of adult mice individually or in mixed treatment groups. In automated group compartments, deprived-reared mice displayed higher locomotor activity, reduced explorative behavior and shifted activity timing compared to enriched-reared mice. Contrastingly, distance and timing of wheel running were largely unaffected by deprived rearing. Our results demonstrate that postweaning social and physical deprivation has measurable effects on mouse locomotor and exploratory behavior, and that such effects may be discernable depending on the activity type studied. Our results further emphasize the importance of the sensitive postweaning period for shaping adult behavioral profiles.

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Hemisphere-specific effects on serotonin but not dopamine innervation in the nucleus accumbens of gerbils caused by isolated rearing and a single early methamphetamine challenge

Cited by 16 publications

References 65 publications

Social stress, therapeutics and drug abuse: Preclinical models of escalated and depressed intake

Social stress, therapeutics and drug abuse: Preclinical models of escalated and depressed intake

Stress responses and the mesolimbic dopamine system: Social contexts and sex differences

Effects of postweaning social and physical deprivation on locomotor activity patterns and explorative behavior in female CD‐1 mice

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