Hemiplegia After Intracarotid Injection of Methylphenidate

Chillar, Ram K.; Jackson, Anthony L.; Alaan, Lorenzo

doi:10.1001/archneur.1982.00510210068021

Cited by 6 publications

(3 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The literature contains several examples of the harms sustained from misuse of methylphenidate. Intravenous use, often of crushed tablets, has been associated with death (Levine, et al, 1986), multiple organ failure (Stecyk, et al, 1985), hemiplegia after intracarotid injection (Chillar, et al, 1982), impaired vision because of talc emboli (Schatz and Drake, 1979) and panlobar emphysema (Stern, et al, 1994). A death has been attributed to intranasal misuse (Massello and Carpenter, 1999) and a stroke following chronic oral misuse (Sadeghian, 2004).…”

Section: Introductionmentioning

confidence: 99%

Safety of therapeutic methylphenidate in adults: a systematic review of the evidence

Godfrey

2008

J Psychopharmacol

View full text Add to dashboard Cite

Attention deficit hyperactivity disorder (ADHD) often persists into adulthood. Stimulant drugs, including methylphenidate, have showed efficacy in trials for ADHD in adults. Adult psychiatrists are likely to encounter increasing numbers of adult patients who may benefit from methylphenidate. A systematic review of the literature was made to examine the evidence on the safety of methylphenidate, when used therapeutically in adults. Twenty-six placebo-controlled trials were found, in which 811 adults received methylphenidate for ADHD and other conditions. In the short term, methylphenidate was well tolerated and no serious side effects were observed. There is little information on the long-term safety of methylphenidate in adults, although the number of serious adverse effects reported to regulatory authorities has, so far, been low. Methylphenidate is associated with a modest rise in blood pressure and heart rate. Surveys of stimulant use in US universities show that misuse of prescribed medication, for recreation or to enhance study, is fairly common although the level of harm that arises from this practice is unclear.

show abstract

Section: Introductionmentioning

confidence: 99%

Safety of therapeutic methylphenidate in adults: a systematic review of the evidence

Godfrey

2008

J Psychopharmacol

View full text Add to dashboard Cite

show abstract

“…The outcomes from the cases involving the radial artery ranged from minimal tissue loss to forearm amputation. 1,[3][4][5][6] Of the cases involving femoral and inguinal injection, pseudo aneurysm formation and anxiety were the main complications reported. 1,4 The two cases of carotid artery injections both resulted in acute contralateral hemiplegia, with one case resolving spontaneously, and the other improving gradually over a number of weeks.…”

mentioning

confidence: 99%

“…1,4 The two cases of carotid artery injections both resulted in acute contralateral hemiplegia, with one case resolving spontaneously, and the other improving gradually over a number of weeks. 5 The development of forearm compartment syndrome following intra-arterial injection of methylphenidate was reported in only one other case report. The patient was treated with intravenous heparin, phentolamine, stellate ganglion block and forearm fasciotomy, however, despite all interventions, a forearm amputation was required after 9 days.…”

mentioning

confidence: 99%