Hemilateral Rhinotomy in the Treatment of Hereditary Hemorrhagic Telangiectasia

Whicker, James H.; Lake, Clifford F.

doi:10.1001/archotol.1972.00770090495004

Cited by 12 publications

(4 citation statements)

References 5 publications

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“…He removed the fragile respiratory epithelium in exchange for a free split skin transplant from the thigh [10]. The original method [10,45] has been modified by several authors; Whicker and Lake [46] improved the access for septal perforations and posterior telangiectases by lateral rhinotomy. Instead of using a skin transplant, other authors have proposed amnion [47], buccal mucosa [14], cultivated epithelial sheets from buccal mucosal cells [48], thick full skin grafts [49] or myocutaneous flaps [50].…”

Section: Septodermoplasty (Saunders)mentioning

confidence: 99%

Treatment of Recurrent Epistaxis in HHT

Geisthoff¹,

Fiorella²,

Fiorella³

2006

CPD

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No optimal treatment modality is currently available for the treatment of recurrent epistaxis in HHT. In this review, different therapeutic concepts are discussed together with their pathophysiologic background. Patients often profess a preventive effect for nasal ointments and use packings which can be self-administered in the case of bleeding. An effective first-line treatment for physicians is the endonasal laser coagulation or argon plasma coagulation. A second line surgical procedure is septodermoplasty according to Saunders which can provide long-lasting relief if performed correctly. There have been reports on antifibrinolytic agents and hormones, but their efficacy has yet to be determined.

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Section: Septodermoplasty (Saunders)mentioning

confidence: 99%

Treatment of Recurrent Epistaxis in HHT

Geisthoff¹,

Fiorella²,

Fiorella³

2006

CPD

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“…Septal dermoplasty was described by Saunders [54,55] in 1960 and has been modified by Whicker and Lake [67] in 1972 using a lateral rhinotomy approach. Septal dermoplasty consists of removal of the mucosa from both sides of the septum and its replacement with a split-thickness skin graft.…”

Section: Has the Patient Been Vaccinated Against Hepatitis B?mentioning

confidence: 99%

Hereditary hemorrhagic telangiectasias: a challenge for the clinician

Bergler

Götte

1999

European Archives of Oto-Rhino-Laryngology

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Hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu disease) remains a challenge for all clinicians, as in about 80% of cases nasal bleeding is the first manifestation of this disease, which is characterized by a clinical triad of multiple telangiectasias, recurrent hemorrhages and familial occurrence. Although in the last few years there has been diagnostic and therapeutic progress, a cure for this rarely life-threatening but often burdening and handicapping disease is still not possible. We have reviewed head and neck presentations, diagnostic and therapeutic features, as well as new insights into the molecular genetics of the disease and local treatment now available.

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“…Durch eine zusätzliche hemilaterale Rhinotomie schufen Whicker und Lake [65] einen erweiterten Zugangsweg, der besonders bei Septumperforationen und posterior gelegenen Gefäßektasien von Vorteil ist. Weitere Modifikationen sind die Deckung mit Amnion [27], bukkaler Mukosa [55], aus bukkaler Mukosa kultivierten Epithellappen [37], dicken Vollhaut- [58] oder Myokutanlappen [5].…”

Section: Brachytherapieunclassified

Behandlung der rezidivierenden Epistaxis beim Morbus Rendu-Osler-Weber

Werner¹,

Geisthoff²,

Lippert³

et al. 1997

HNO

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Rendu-Osler-Weber disease is an autosomally dominant inherited disease which affects the connective tissue of blood vessels. The major symptom is recurrent epistaxis for which still exists no generally recommended treatment. Treatment modalities discussed in the literature include bilateral closure of the nostrils, brachytherapy, vessel embolization, hormone therapy, dermoplasties, as well as different kinds of laser therapies. Advantages and disadvantages of single treatment modalities are discussed. Dermoplasty and laser therapy seem to be the most suitable treatment procedures currently available for recurrent epistaxis in affected patients. Treatment carried out with the argon, KTP or ND:YAG laser has proven to be suitable as initial therapy. In most cases the additional use of long-term applications of a soft nasal ointment allows a lasting successful treatment. Our experiences show that dermoplasty should be reserved for cases with continued bleeding despite laser treatment but only rarely offers a long-term cure in the sense of a total recovery from epistaxis.

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Hemilateral Rhinotomy in the Treatment of Hereditary Hemorrhagic Telangiectasia

Cited by 12 publications

References 5 publications

Treatment of Recurrent Epistaxis in HHT

Treatment of Recurrent Epistaxis in HHT

Hereditary hemorrhagic telangiectasias: a challenge for the clinician

Behandlung der rezidivierenden Epistaxis beim Morbus Rendu-Osler-Weber

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