Hemicurcuminoids (1-styryl-1,3-diketones) – valuable multi-faceted building blocks for organic synthesis

Zimnitskiy, Nikolay S.; Korotaev, Vladislav Yu.; Barkov, Alexey Yu.; Кочнев, Иван А.; Sosnovskikh, Vyacheslav Ya.

doi:10.1039/d2nj04338f

New J. Chem.

2023

DOI: 10.1039/d2nj04338f

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Hemicurcuminoids (1-styryl-1,3-diketones) – valuable multi-faceted building blocks for organic synthesis

Nikolay S. Zimnitskiy

Vladislav Yu. Korotaev

Alexey Yu. Barkov

et al.

Abstract: For the first time, a review has been conducted on methods for synthesis as well as chemical, physical and biological properties of 5-arylpent-4-ene-1,3-diones (hemicurcuminoids). Most prominent pathways for construction of...

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2024

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The First Crystal Structure of an Anti-Geometric Homoleptic Zinc Complex from an Unsymmetric Curcuminoid Ligand

Obregón Mendoza,

Escamilla,

Tavera-Hernández

et al. 2024

Crystals

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Curcuminoids are widely studied due to their well-recognized therapeutic properties. These molecules are often derivatized with metals, producing their corresponding homoleptic metal complexes. Numerous crystal structures of homoleptic symmetric curcuminoids with physiologically essential metals are known, although the literature lacks reports of homoleptic metal complexes of unsymmetric curcuminoids (or hemi-curcuminoids) as ligands. Three unknowns must be solved when an unsymmetric curcuminoid ligand is reacted with a metal ion: (a) the degree of coordination (MLn); (b) the spatial geometry; and (c) the conformational nature (syn or anti) of the complex. Herein, we report the structure of the anti-isomer of the Zn complex of the hemi-curcuminoid 5-hydroxy-1-(4-methoxyphenyl)hexa-1,4-dien-3-one. While the NMR shows only one set of signals for this homoleptic complex, the unambiguous stereochemistry was established through single-crystal X-ray diffractometry, revealing an anti-hexacoordinated octahedral ML2 structure.

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The First Crystal Structure of an Anti-Geometric Homoleptic Zinc Complex from an Unsymmetric Curcuminoid Ligand

Obregón Mendoza,

Escamilla,

Tavera-Hernández

et al. 2024

Crystals

View full text Add to dashboard Cite

show abstract

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Hemicurcuminoids (1-styryl-1,3-diketones) – valuable multi-faceted building blocks for organic synthesis

Abstract: For the first time, a review has been conducted on methods for synthesis as well as chemical, physical and biological properties of 5-arylpent-4-ene-1,3-diones (hemicurcuminoids). Most prominent pathways for construction of...

Cited by 1 publication

References 169 publications

The First Crystal Structure of an Anti-Geometric Homoleptic Zinc Complex from an Unsymmetric Curcuminoid Ligand

The First Crystal Structure of an Anti-Geometric Homoleptic Zinc Complex from an Unsymmetric Curcuminoid Ligand

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