Heme Oxygenase-1 Reduces Sepsis-Induced Endoplasmic Reticulum Stress and Acute Lung Injury

Chen, Xiao-Zhen; Wang, Yinglin; Xie, Xiang; Chen, Hongfei; Zhu, Qiqi; Ge, Zhi‐Dong; Wei, Hua; Deng, Jianping; Xia, Zhengyuan; Lian, Qingquan

doi:10.1155/2018/9413876

Cited by 72 publications

(58 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The majority of free radicals observed are superoxide (O 2 − ), hydroxyl (OH − ), hydroperoxide (HO 2 − ), nitric oxide (NO • ), and nitrogen dioxide (NO 2 • ). Among these, the hydroxyl radical is the most reactive in the induction of cellular lesions and hydrogen peroxide can cross the nuclear membrane and induce damage in the DNA molecule [ 119 , 120 ].…”

Section: Anti-inflammatory Molecules Of Medicinal Plants and Mechamentioning

confidence: 99%

Plants as Sources of Anti-Inflammatory Agents

et al. 2020

View full text Add to dashboard Cite

Plants represent the main source of molecules for the development of new drugs, which intensifies the interest of transnational industries in searching for substances obtained from plant sources, especially since the vast majority of species have not yet been studied chemically or biologically, particularly concerning anti-inflammatory action. Anti-inflammatory drugs can interfere in the pathophysiological process of inflammation, to minimize tissue damage and provide greater comfort to the patient. Therefore, it is important to note that due to the existence of a large number of species available for research, the successful development of new naturally occurring anti-inflammatory drugs depends mainly on a multidisciplinary effort to find new molecules. Although many review articles have been published in this regard, the majority presented the subject from a limited regional perspective. Thus, the current article presents highlights from the published literature on plants as sources of anti-inflammatory agents.

show abstract

Section: Anti-inflammatory Molecules Of Medicinal Plants and Mechamentioning

confidence: 99%

Plants as Sources of Anti-Inflammatory Agents

et al. 2020

View full text Add to dashboard Cite

show abstract

“…23,24 Previous studies have demonstrated that ERS response played an important role in apoptosis in sepsis cells. 25,26 However, it is not clear whether ERS is involved in the function of miR-547 in sepsis-induced ALI.…”

mentioning

confidence: 99%

Up‐regulation of microRNA‐574 attenuates lipopolysaccharide‐ or cecal ligation and puncture‐induced sepsis associated with acute lung injury

Sun

2020

Cell Biochemistry & Function

View full text Add to dashboard Cite

Acute lung injury (ALI) is the most vulnerable organ in sepsis, however, its underlying mechanism remains unclear. Cell viability and apoptosis were detected by cell counting kit-8 and flow cytometry. The expressions of miR-574, Complement 3 (C3), glucose regulatory protein 78 (GRP78), C/EBP homologous protein (CHOP) and Caspase-12 were determined using quantitative real time (qRT)-PCR and Western blot. Histopathology of mice was stained by haematoxylin and eosin staining. The levels of tumour necrosis factor-α (TNF-α) and interleukin (IL)-1β were determined using ELISA. The expression of miR-574 was positively correlated with cell viability in lipopolysaccharide (LPS)-treated cells. Cell viability was improved and apoptosis was inhibited by mimics. Meanwhile, the levels of GRP78, CHOP and Caspase-12 were suppressed by mimics and agomir in LPS-treated human bronchial epithelial (HBE) cells and cecal ligation and puncture (CLP)-treated mice. In vivo, lung tissue damages were ameliorated by agomir, which also decreased the levels of neutrophils, macrophages and albumin. C3 was a target gene of miR-574 and could be decreased by mimics. SiC3 enhanced cell viability and inhibited apoptosis, however, it suppressed the mRNA levels of GRP78, CHOP and Caspase-12. Up-regulation of miR-574 attenuated sepsis-induced lung injury may be by promoting C3 down-regulation and reducing sepsis-induced endoplasmic reticulum stress (ERS). Significance of the study: Clinically, the mortality rate of ALI induced by sepsis remains at a high level, thus, clarifying the mechanism of induction of ALI through pathogen infection will provide a new target for clinical treatment of ALI. In this study, up-regulation of miR-574 attenuated sepsis-induced lung injury may be by promoting C3 down-regulation and reducing sepsis-induced ERS. Our study provides a deeper understanding of sepsis.

show abstract

“…there several studies indicating its positive role in treatment of sepsis [44,45]. Considering future directions, it could be proposed that search for epigenetic modulators of ensemble gene noise might represent a novel pharmaceutical avenue for adjuvant treatments of sepsis.…”

Section: Because Viral/bacterial Infections and Sepsis Results In Overmentioning

confidence: 99%

Discovery of pharmaceutically-targetable pathways and prediction of survivorship for pneumonia and sepsis patients from the view point of ensemble gene noise

Guryev

Moshkin

2020

Preprint

View full text Add to dashboard Cite

Finding novel biomarkers for human pathologies and predicting clinical outcomes for patients is rather challenging. This stems from the heterogenous response of individuals to disease which is also reflected in the inter-individual variability of gene expression responses. This in turn obscures differential gene expression analysis (DGE). In the midst of the COVID-19 pandemic, we wondered whether an alternative to DGE approaches could be applied to dissect the molecular nature of a host-response to infection exemplified here by an analysis of H1N1 influenza, community/hospital acquired pneumonia (CAP) and sepsis. To this end, we turned to the analysis of ensemble gene noise. Ensemble gene noise, as we defined it here, represents a variance within an individual for a collection of genes encoding for either members of known biological pathways or subunits of annotated protein complexes. From the law of total variance, ensemble gene noise depends on the stoichiometry of the ensemble genes' expression and on their average noise (variance). Thus, rather than focusing on specific genes, ensemble gene noise allows for the holistic identification and interpretation of gene expression disbalance on the level of gene networks and systems. Comparing H1N1, CAP and sepsis patients we spotted common disturbances in a number of pathways/protein complexes relevant to the sepsis pathology which lead to an increase in the ensemble gene noise. Among others, these include mitochondrial respiratory chain complex I and peroxisomes which could be readily targeted for adjuvant treatment by methylene blue and 4-phenylbutyrate respectively. Finally, we showed that ensemble gene noise could be successfully applied for the prediction of clinical outcome, namely mortality, of CAP and sepsis patients. Thus, we conclude that ensemble gene noise represents a promising approach for the investigation of molecular mechanisms of a pathology through a prism of alterations in coherent expression of gene circuits.

show abstract

Heme Oxygenase-1 Reduces Sepsis-Induced Endoplasmic Reticulum Stress and Acute Lung Injury

Cited by 72 publications

References 52 publications

Plants as Sources of Anti-Inflammatory Agents

Plants as Sources of Anti-Inflammatory Agents

Up‐regulation of microRNA‐574 attenuates lipopolysaccharide‐ or cecal ligation and puncture‐induced sepsis associated with acute lung injury

Discovery of pharmaceutically-targetable pathways and prediction of survivorship for pneumonia and sepsis patients from the view point of ensemble gene noise

Contact Info

Product

Resources

About