Heme oxygenase-1 expression predicts cervical lymph node metastasis of tongue squamous cell carcinomas

Abstract

Heme oxygenase-1 (HO-1) is known as a stress-inducible protein. The presesnt study is designed to investigate the relationship between HO-1 expression levels and clinical features of tongue cancer by using HO-1 responsiveness to stress as a clinical indicator. One hundred and twelve biopsy samples from tongue squamous cell

Polymorphism in heme oxygenase-1 (HO-1) promoter is related to the risk of oral squamous cell carcinoma occurring on male areca chewers

“…Such phenotypes are advantageous for tumour progression and survival. However, a recent paper, denoting the lower HO-1 expression in head and neck carcinomas with LNM, has argued that the increase of HO-1 expression as a cause or a consequence of carcinogenesis (Yanagawa et al, 2004). Preliminary evidences from us indicated that HO-1 promoter polymorphism had no impact on tumour progression, reflecting by metastasis or advanced clinical stage.…”

“…Since buccal mucosa is the primary site for the insults of areca, buccal squamous cell carcinoma (BSCC) is the most common subset of OSCC accounting for more than 60% of OSCC in South Asians (Lin et al, 2000;Kao et al, 2002;Lo et al, 2003;Wong et al, 2003). It was found that a subset of OSCC, which occurred on tongue with higher HO-1 expression, contained significantly more differentiated samples and cases without lymph node involvement, which implicated that HO-1 expression could be disadvantageous for OSCC progression (Yanagawa et al, 2004).…”

“…However, the association between HO-1 promoter polymorphism and cancer risk has not been established. Although HO-1 expression might be related to the biological behaviour of OSCC (Yanagawa et al, 2004), the involvement of functional HO-1 polymorphisms in the risk of oral diseases has not been defined. We hypothesised that higher (GT) n repeats may be associated with the risk of OSCC and OSF.…”

Antiproliferative effect of oleuropein in prostate cell lines

“…In cancer, HO-1 has been described as a pro-tumoural molecule due to its antiapoptotic effects on colon cancer and hepatoma on murine models and its proangiogenic effects in human pancreatic cancer (52,53). By contrast, in human tongue cancer, low HO-1 expression has been associated with an increased risk of developing lymph node metastasis (54).…”

The Gα12/13 Family of Heterotrimeric G Proteins and the Small GTPase RhoA Link the Kaposi Sarcoma-associated Herpes Virus G Protein-coupled Receptor to Heme Oxygenase-1 Expression and Tumorigenesis

“…Similarly, the zinc protoporphyrin, another potent HO-1 inhibitor, has an antineoplastic effect in rats and mice bearing tumors derived from hepatoma and human colon cancer cells (9,76) and also reduces vGPCR-induced tumor growth by 80% (data not shown). Recent evidence shows that HO-1 is overexpressed in pancreatic, gastric, lung, and renal cancer, myeloid leukemia, melanoma, glioma, tongue, thyroid, and hepatocarcinomas (8,12,13,60,61,64,65,70,(75)(76)(77)(78)(79)(80)(81)(82)(83), which are some of the cancer types where RhoA is also overexpressed. Although the link between HO-1 expression and aberrant cell growth is starting to be unraveled, metalloporphyrins that inhibit HO-1 deserve further studies as antitumoral drugs.…”