Heme oxygenase-1: Equally important in allogeneic hematopoietic stem cell transplantation and organ transplantation?

Verheij, Myrddin W.; Voermans, Carlijn

doi:10.1016/j.trim.2021.101419

Cited by 5 publications

(2 citation statements)

References 60 publications

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“…Among them, bilirubin protects cells from lipid-induced damage and prevents LDL peroxidation ( Stocker et al, 1987 ; Boon et al, 2012 ), thereby slowing down the process of atherosclerosis. After hemin administration, they are catalyzed by HO-1 to generate biliverdin, carbon monoxide (CO), and ferrous iron ( Verheij et al, 2021 ). Biliverdin is subsequently transformed into bilirubin.…”

Section: Discussionmentioning

confidence: 99%

Induction of Heme Oxygenase-1 Modifies the Systemic Immunity and Reduces Atherosclerotic Lesion Development in ApoE Deficient Mice

et al. 2022

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Heme oxygenase-1 (HO-1) has been reported to protect against oxidation and inflammation in atherosclerosis. It remains unclear how the immune system participates in the cytoprotective function of HO-1 in the context of atherosclerosis. In this study, we attempted to investigate the potential effect of a HO-1 inducer, hemin, and a HO-1 inhibitor, Tin-protoporphyrin IX (SnPP), on the progression of atherosclerosis in ApoE deficient mice. Using mass cytometry, 15 immune cell populations and 29 T cell sub-clusters in spleen and peripheral blood were thoroughly analyzed after hemin or SnPP treatment. SnPP elevated risk factors of atherosclerosis, whereas hemin reduced them. In-depth analysis showed that hemin significantly modified the immune system in both spleen and peripheral blood. Hemin increased dendritic (DC) and myeloid-derived suppressor cells (MDSCs), but decreased natural killer (NK) cells. An opposite effect was observed with SnPP treatment in terms of NK cells. NK cells and MDSCs were positively and negatively correlated with total cholesterol and low-density lipoprotein, respectively. Moreover, the T cell profiles were significantly reshaped by hemin, whereas only minor changes were observed with SnPP. Several hemin-modulated T cell clusters associated with atherosclerosis were also identified. In summary, we have unraveled an important regulatory role for HO-1 pathway in immune cell regulation and atherosclerosis. Our finding suggests that modulating HO-1 signaling represents a potential therapeutic strategy against atherosclerosis.

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Section: Discussionmentioning

confidence: 99%

Induction of Heme Oxygenase-1 Modifies the Systemic Immunity and Reduces Atherosclerotic Lesion Development in ApoE Deficient Mice

et al. 2022

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“…HO-1 plays a critical role in metabolizing the cell-free form of heme, which is released during cell apoptosis and tissue damage. Thus, HO-1 exerts its protective activity in different disease settings such as ischemia-reperfusion injury and graft versus host disease [59]. It is also an immunomodulatory mediator that MSCs produce and employ [60].…”

Section: Anti-inflammatory Mediator: Ido Ho-1 Hgfmentioning

confidence: 99%

Preconditioned Mesenchymal Stromal Cells to Improve Allotransplantation Outcome

Cheng

Anggelia

Lin

et al. 2021

Cells

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Mesenchymal stromal cells (MSCs) are tissue-derived progenitor cells with immunomodulatory as well as multilineage differentiation capacities, and have been widely applied as cellular therapeutics in different disease systems in both preclinical models and clinical studies. Although many studies have applied MSCs in different types of allotransplantation, the efficacy varies. It has been demonstrated that preconditioning MSCs prior to in vivo administration may enhance their efficacy. In the field of organ/tissue allotransplantation, many recent studies have shown that preconditioning of MSCs with (1) pretreatment with bioactive factors or reagents such as cytokines, or (2) specific gene transfection, could prolong allotransplant survival and improve allotransplant function. Herein, we review these preconditioning strategies and discuss potential directions for further improvement.

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Heme Oxygenase-1, Cardiac Senescence, and Myocardial Infarction: A Critical Review of the Triptych

Padda,

Sethi,

Das

et al. 2024

Cardiovasc Drugs Ther

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Heme oxygenase-1: Equally important in allogeneic hematopoietic stem cell transplantation and organ transplantation?

Cited by 5 publications

References 60 publications

Induction of Heme Oxygenase-1 Modifies the Systemic Immunity and Reduces Atherosclerotic Lesion Development in ApoE Deficient Mice

Induction of Heme Oxygenase-1 Modifies the Systemic Immunity and Reduces Atherosclerotic Lesion Development in ApoE Deficient Mice

Preconditioned Mesenchymal Stromal Cells to Improve Allotransplantation Outcome

Heme Oxygenase-1, Cardiac Senescence, and Myocardial Infarction: A Critical Review of the Triptych

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