Heme biosynthesis regulates BCAA catabolism and thermogenesis in brown adipose tissue
Dylan J. Duerre,
Julia K. Hansen,
Steven John
et al.
Abstract:With age, people tend to accumulate body fat and reduce energy expenditure1. Brown (BAT) and beige adipose tissue dissipate heat and increase energy expenditure via the activity of the uncoupling protein UCP1 and other thermogenic futile cycles2,3. The activity of brown and beige depots inversely correlates with BMI and age4–11, suggesting that promoting thermogenesis may be an effective approach for combating age-related metabolic disease12–15. Heme is an enzyme cofactor and signaling molecule that we recentl… Show more
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