Hematuria Screening Test for Urinary Bladder Mucosal Infiltration in Cervical Cancer

Chuttiangtum, Ayuth; Udomthavornsuk, Banchong; Chumworathayi, Bandit

doi:10.7314/apjcp.2012.13.10.4931

Cited by 6 publications

(9 citation statements)

References 9 publications

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“…Cervical cancer). In gynecologic section, it was demonstrated that hematuria can be used as a screening test to detect urinary bladder mucosal infiltration of cervical cancer (Chuttiangtum et al, 2012). It has been reported that Urological cancer is found in approximately 5% of the patients presenting with microscopic hematuria, and in around 20% of the patients with gross hematuria (Khadra et al, 2000;Cohen and Brown, 2003).…”

Section: Discussionmentioning

confidence: 99%

External Validation of a Clinical Scoring System for Hematuria

Lee

Kim

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: The aim of this study was to evaluate the accuracy of a new scoring system in Korean patients with hematuria at high risk of bladder cancer. Materials and Methods: A total of 319 consecutive patients presenting with painless hematuria without a history of bladder cancer were analyzed, from the period of August 2012 to February 2014. All patients underwent clinical examination, and 22 patients with incomplete data were excluded from the final validation data set. The scoring system included four clinical parameters: age (≥50 = 2 vs. <50 =1), gender (male = 2 vs. female = 1), history of smoking (smoker/ex-smoker = 4 vs. non-smoker = 2) and nature of the hematuria (gross = 6 vs. microscopic = 2). Results: The area under the receiver-operating characteristic curve (95% confidence interval) of the scoring system was 0.718 (0.655-0.777). The calibration plot demonstrated a slight underestimation of bladder cancer probability, but the model had reasonable calibration. Decision curve analysis revealed that the use of model was associated with net benefit gains over the treat-all strategy. The scoring system performed well across a wide range of threshold probabilities (15%-45%). Conclusions: The scoring system developed is a highly accurate predictive tool for patients with hematuria. Although further improvements are needed, utilization of this system may assist primary care physicians and other healthcare practitioners in determining a patient's risk of bladder cancer.

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Section: Discussionmentioning

confidence: 99%

External Validation of a Clinical Scoring System for Hematuria

Lee

Kim

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Snyman et al described the urine cytology for nonurological tumors as having a sensitivity of 94 % and a specificity of 82 % [8]. In accordance with Chuttiangtum et al [6] they indicated invasive investigation of the urinary tract by cystoscopy in patients with positive cytology.…”

Section: Laboratory Testingmentioning

confidence: 73%

“…Sensitivity was calculated to be 100 % with a specificity of 60.3 %. The authors concluded that hematuria might be a good tool for deciding whether further examination (e.g., cystoscopy) is necessary [6].…”

Section: Laboratory Testingmentioning

confidence: 99%

Management of Nonurological Pelvic Tumors Infiltrating the Lower Urinary Tract

et al. 2014

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Locally advanced tumors, originating from organs and structures of the pelvis and the pelvic floor may compromise the lower urinary tract. The aim of this review is to display the diagnosis and treatment of the most common malignancies infiltrating the lower urinary tract. A review was performed of the literature in PubMed over the last two decades. The most common nonurological pelvic tumors infiltrating the lower urinary tract are colorectal cancer, gynecological tumors, and sarcomas. For diagnosis, multiple non-invasive and invasive options are available and their use is partially tumor-specific. If infiltration to adjacent structures is given, en bloc resection should be performed to achieve clear margins. However, despite oncological considerations a bladder-sparing resection is often possible. Neoadjuvant or adjuvant therapy approaches are also tumorspecific. The overall 3-year survival rate is about 40 %. Nonurological tumors that infiltrate the lower urinary tract should be given multidisciplinary treatment. The patient's personal decision regarding acceptance of the surgical extent with possibly persistent disability should be considered.

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“…10 In urology clinics, the presence of microscopic haematuria has long been used as a screening test to identify patients with possible urological malignancy, with current guidelines recommending further investigation with imaging and cystoscopy if it is found. 11,12 The primary aim of our study was to evaluate whether the absence of microscopic haematuria can be used as a screening test to exclude invasion of the urinary bladder by cervical cancer and therefore reduce the need for a staging cystoscopy.…”

Section: Introductionmentioning

confidence: 99%

The use of microscopic haematuria can reduce the need for staging cystoscopy to exclude invasion of the urinary bladder by cervical carcinoma

Vlok

Wessels

Toit

et al. 2021

Southern African Journal of Gynaecological Oncology

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Previous literature indicates that the detection of haematuria on urine microscopy, to exclude bladder invasion by cervical cancer, has a high specificity. It also aids the evaluation of whether a patient needs a staging cystoscopy or not. The purpose of this study was to replicate these findings, and also to determine whether a urinary dipstick test for microscopic haematuria can be used as a screening test to identify bladder invasion by cervical cancer. Methods: A prospective observational study was conducted from January 2015 until December 2016 at a tertiary referral centre. It included all patients with newly diagnosed stage 2 or higher cervical cancer who received a staging cystoscopy at the authors' institution. Urine was collected by means of catheterisation and sent for urinary dipstick test and urine microscopy. Microscopy results were compared with cystoscopy findings. Results: Urinary dipstick testing for microscopic haematuria was performed on 143 patients. The sensitivity of the test was 1 and the specificity was 0.85. The negative predictive value was 1 and the positive predictive value was 0.5. With urine microscopy for haematuria, if more than 10 000 erythrocytes per millilitre was used for defining microscopic haematuria, the sensitivity was 1, the specificity 0.8, the positive predictive value 0.43 and the negative predictive value 1. Conclusion:The presence of microhaematuria can be used as a screening test to predict possible invasion of the urinary bladder by cervical cancer, and can thus be used to identify patients needing cystoscopy. Urine dipstick testing (Bayer Multix 10SG dipstick) provided statistically similar results to urine microscopy (if >10 000 erythrocytes equates microhaematuria) to identify patients needing cystoscopy.

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Hematuria Screening Test for Urinary Bladder Mucosal Infiltration in Cervical Cancer

Cited by 6 publications

References 9 publications

External Validation of a Clinical Scoring System for Hematuria

External Validation of a Clinical Scoring System for Hematuria

Management of Nonurological Pelvic Tumors Infiltrating the Lower Urinary Tract

The use of microscopic haematuria can reduce the need for staging cystoscopy to exclude invasion of the urinary bladder by cervical carcinoma

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