Hematuria macroscópica persistente como presentación de nefropatía por IgA

Arriola, Mariano Tomás

doi:10.1016/j.nefro.2021.07.016

Cited by 1 publication

(1 citation statement)

References 4 publications

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“…It is closely related to diabetes, hypertension and coronary heart disease, and seriously affects health. [1][2][3][4] The global incidence of CKD is increasing at an average annual rate of 8%, and currently, more than 100 million people need dialysis for survival. 5 Therefore, strategies to reduce renal damage in such patients are necessary.…”

Section: Introductionmentioning

confidence: 99%

Effects of electroacupuncture at KI3 and ST36 on the hypothalamic paraventricular nucleus in a rat model of chronic glomerulonephritis

et al. 2023

Acupunct Med

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Objective: The hypothalamic paraventricular nucleus (PVN) acts as a critical integrating center of endocrine/autonomic responses and regulates visceral functional activities. However, its involvement in electroacupuncture (EA) treatment of chronic glomerulonephritis (CGN) remains unclear. Methods: Over four experiments, we randomized 111 rats into: control, untreated model (CGN) or EA-treated model (CGN + EA) groups, a model group receiving EA after PVN damage (CGN + EA + Lesion) or untreated model groups injected with adeno-associated viral vectors encoding human M4 muscarinic receptor (CGN + hM4D) or enhanced green fluorescent protein (CGN + EGFP). CGN was modeled by intraperitoneal injection of bovine serum albumin for 2 weeks. Rats in the CGN + EA and CGN + EA + Lesion groups received EA at bilateral ST36 and KI3 for 14 days. Urine/serum samples were collected to evaluate inflammatory factors and changes in renal function. Results: EA inhibited the release of interleukin (IL)-6, tumor necrosis factor (TNF)-α and IL-1β, and decreased urine protein (PRO), creatinine (Cre) and blood urea nitrogen (BUN) levels. PVN damage influenced the effect of EA on the levels of these parameters. EA appeared to inhibit the firing frequency and spectral energy of PVN neurons. In the viral vector experiment, levels of PRO, Cre, IL-6, IL-1β and TNF-α in the CGN group were increased in CGN versus control groups ( p < 0.0001), decreased in CGN + hM4D versus CGN groups ( p < 0.05) and did not differ between CGN + EGFP and control groups ( p > 0.05). Conclusion: Our findings indicate that EA at ST36 and KI3 improves CGN in this rat model by weakening the activity of PVN neurons, alleviating impairment of renal function impairment and restricting the release of inflammatory factors.

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Section: Introductionmentioning

confidence: 99%

Effects of electroacupuncture at KI3 and ST36 on the hypothalamic paraventricular nucleus in a rat model of chronic glomerulonephritis

et al. 2023

Acupunct Med

View full text Add to dashboard Cite

show abstract

Hematuria macroscópica persistente como presentación de nefropatía por IgA

Cited by 1 publication

References 4 publications

Effects of electroacupuncture at KI3 and ST36 on the hypothalamic paraventricular nucleus in a rat model of chronic glomerulonephritis

Effects of electroacupuncture at KI3 and ST36 on the hypothalamic paraventricular nucleus in a rat model of chronic glomerulonephritis

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