Hematuria Due to Hyperuricosuria (HU): 30 Months Follow-Up

Perrone, Heloisa Cattini; Toporovski, Júlio; Schor, Nestor

doi:10.1007/978-1-4615-2556-1_270

Cited by 2 publications

(3 citation statements)

References 1 publication

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“…The observation of a 33% hematuria rate in the metabolic group and a 26% dysuria rate in the infection group is clinically significant. Many studies reported that urinated oxalate, uric acid and calcium caused hematuria by damaging the uroepithelium, and in these cases urinary N-acetyl-glucoseaminoglycan (NAG) levels, as a marker of tubular injury, were elevated [26][27][28]. These previous findings support the association of metabolic etiology and hematuria.…”

Section: Discussionmentioning

confidence: 60%

The metabolic etiology of urolithiasis in Turkish children

et al. 2009

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Pediatric urolithiasis is an endemic disease, especially in certain developing regions of the world, such as the Far East, and to a certain extent the Middle East and Turkey. The aim of the study is to determine the metabolic etiology and the prevalence of formation of urinary calculi in Turkish pediatric patients with urolithiasis. Seventy-two pediatric patients diagnosed as having urolithiasis were studied from 1999-2005 in Dr. Behcet Uz Child Disease and Surgery Education and Research Hospital Nephrology Department, Izmir, according to their presenting signs and clinical and laboratory findings. The other necessary tests were also applied to detect the etiology of the calculi formation. Of the 72 patients, 50 (69.4%) were male and 22 (30.6%) were female, with ages ranging from 2 to 168 months (mean age 72 +/- 35.7 months), and the male-to-female ratio of patients was 2.3. Twenty-four (33%) of them were diagnosed as having metabolic urolithiasis, 21 (30%) anatomic, 19 (26%) infectious and 8 (11%) idiopathic. The age at which urolithiasis was first diagnosed was found to be low in the metabolic and anatomic etiology groups (P = 0.028). Thirteen patients (18%) with urolithiasis were known to have a family history of stone disease, and in all of them metabolic etiology was considered to be the reason (P < 0.001). In all of the groups, the localization of the stone was found to be the upper urinary system most of the time, and in 17 (24%) with bilateral multiple stones, the etiology was found to be metabolic (P < 0.001). All of the patients were followed up for 3-72 months (mean 29.2 +/- 13.7 months), and four of them (5.5%) had recurrences. In order to prevent renal damage and recurrences in pediatric patients with urolithiasis in Turkey in whom the etiology is mostly metabolic, the illnesses must be investigated very cautiously, and their early diagnosis and treatment modalities must be considered.

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Section: Discussionmentioning

confidence: 60%

The metabolic etiology of urolithiasis in Turkish children

et al. 2009

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“…If adenoviruses, a known etiology of acute hemorrhagic cystitis in children [19], are considered, then it is plausible that some of the patients in the "unproven urinary tract infection" category could have been assigned this diagnosis. In more-recent years, the common association between gross hematuria and idiopathic hypercalciuria and hyperuricosuria has become more apparent [20][21][22], and a significant number of the patients in the latter two groups (above) might well have had one of these conditions. These patients present with asymptomatic gross hematuria or symptoms suggestive of a urinary tract infection (i.e., abdominal pain, dysuria, frequency, and urgency).…”

Section: Gross Hematuriamentioning

confidence: 99%

“…Thus, analysis of a random urine for calcium and creatinine would seem appropriate. If there is a family history of urolithiasis, a personal history of excessive dietary calcium intake, or a urine Ca/Cr greater than 0.20 [25], a 24-h urine collection for calcium is appropriate (normal <4 mg/kg per 24 h) [22,25]. At the same time, urinary uric acid values (normal <0.57 mg/dl glomerular filtrate in a 24-h urine sample) may be indicated [25].…”

Section: Asymptomatic Microscopic (Isolated) Hematuriamentioning

confidence: 99%

A practical primary care approach to hematuria in children

Diven¹,

Travis²

2000

Pediatric Nephrology

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Although hematuria is a common finding in the unselected population of children, the approach to evaluation is quite variable. Changes in the practice of primary care medicine in the United States mandate an approach to common office problems that is practical and realistic. This review addresses three areas: the current approach to evaluation of hematuria in children, a classification of children with hematuria into four distinct and easily identified clinical categories, and the development of an algorithm for application in the primary care setting. Each category is discussed relative to the more-common etiologies of hematuria, with recommendations for appropriate evaluation as well as suggestions of an appropriate referral to the nephrologist. An algorithm is proposed that provides a practical, systematic approach to the problem without the requirement for a specific diagnosis in every patient. The proposed classification and approach to the evaluation of children with hematuria should help simplify and clarify a potentially complex process.

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Hematuria Due to Hyperuricosuria (HU): 30 Months Follow-Up

Cited by 2 publications

References 1 publication

The metabolic etiology of urolithiasis in Turkish children

The metabolic etiology of urolithiasis in Turkish children

A practical primary care approach to hematuria in children

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