Hematuria as an adverse outcome following provocative growth hormone stimulation testing in children

Abstract

In this study of children undergoing GH testing, hematuria was identified in three subjects. This study demonstrates that side effects to agents used for GH testing are self-limited, yet not rare, and should be discussed with patients and families prior to stimulation testing.

Myalgia and Hematuria in Association with Clonidine and Arginine Administration for Growth Hormone Stimulation Tests

“…e prevalence of micro-and macroscopic hematuria in children undergoing GH stimulation testing was measured in a study of 34 subjects undergoing GH stimulation testing using mainly clonidine and arginine [30]. ree subjects (all male; aged 9-12 years) developed hematuria that resolved spontaneously within 7 days of testing, which is congruent with our patient's history.…”

“…e potential pathophysiology of arginine-related hematuria is poorly understood. It has been proposed that transient hypotension experienced by patients who received GH stimulation testing with both clonidine and arginine may cause nephritic changes and subsequent hematuria [30]. Although hematuria can be a marker of glomerular barrier damage, none of the patients in the aforementioned study or our patient had evidence of persistent renal disease.…”

“…Although the limited number of reports, small sample size, and the search of select databases are limitations, the data suggest that hematuria may be an underrecognized side effect of GH testing, and seem more common with arginine. Further studies are needed to clarify how common this association is [30].…”

An obscure case of chronic unilateral hematuria bleeding point

“…It has also reported that gross hematuria occurs in a growth hormone stimulation test. 3 In this case, growth hormone was discontinued to check for improvement in the hematuria, but there was no improvement. In this case, there was no causal relationship between the hematuria and growth hormone administration.…”