Hematopoyesis extramedular: ¿mecanismo compensador o síndrome clínico? Descripción de un caso y revisión bibliográfica

Rosada, Javier; Bindi, Massimo; Pinelli, Massimiliano; Pandolfo, C.; Cassetti, Giuseppina; Castiglioni, Maido

doi:10.4321/s0212-71992007000200007

Cited by 5 publications

(7 citation statements)

References 33 publications

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“…1,2 While the entity of EMH and its associated conditions have long been recognized, the specific mechanisms giving rise to EMH are unknown and remain as postulates. 1,[15][16][17][18][19][20][21] Herein, we describe a patient with myelofibrosis who presented with neurologic complaints, was found to have intracranial lesions by imaging studies, and in whom CSF cytology supported a diagnosis of intracranial EMH. 5,6 Intracranial EMH is extremely rare and such patients can present with headache, papilledema, visual-field defects, seizures, and hydrocephalus, or be asymptomatic.…”

Section: Introductionmentioning

confidence: 94%

A common complication of myelofibrosis presenting as a rare finding in cerebrospinal fluid cytology

Ruíz-Cordero

Jorgensen

Krishnamurthy

et al. 2017

Diagnostic Cytopathology

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Herein, we present a rare case of intracranial extramedullary hematopoiesis (EMH) diagnosed by cerebrospinal fluid (CSF) cytology and describe the clinical presentation, radiologic, and pathologic findings. A 65 year-old man with a history of progressing primary myelofibrosis was admitted for headaches and right facial numbness. A brain MRI revealed focal abnormalities that were suspicious for leptomeningeal involvement of acute leukemia. Cytologic examination of CSF demonstrated a hypercellular specimen composed of hematopoietic cells including few blasts, as well as maturing red blood cells and granulocytic cells. The integration of morphologic findings, peripheral blood and bone marrow counts, as well as flow cytometric analysis of CSF and bone marrow, excluded leptomeningeal involvement by leukemic blasts and helped establish the diagnosis of intracranial EMH. Inclusion of EMH in the differential diagnosis of intracranial pathology in patients with known conditions predisposing them to EMH is important because recognizing this rare event has implications for treatment and prognosis.

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Section: Introductionmentioning

confidence: 94%

A common complication of myelofibrosis presenting as a rare finding in cerebrospinal fluid cytology

Ruíz-Cordero

Jorgensen

Krishnamurthy

et al. 2017

Diagnostic Cytopathology

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“…Es un proceso habitual en la vida fetal pero considerado anormal en la edad adulta 2 . La HE es un mecanismo compensador en diversas enfermedades hematoló gicas [1][2][3] . La localizació n presacra es poco frecuente y existen pocos casos descritos en la bibliografía mé dica.…”

Section: Sr Editorunclassified

“…Se asocia a talasemia, anemia de cé lulas falciformes, esferocitosis hereditaria, mielofibrosis con metaplasia mieloide, pú rpura trombocitopé nica inmune, leucemia mieloide cró nica, linfoma de Hodgkin, policitemia vera, síndromes mielodisplá sicos y enfermedad de Paget. Tanto la anemia cró nica como la hipoxia tisular producen una estimulació n de la eritropoyesis celular tanto intramedular como extramedular [1][2][3][4][5] . La asociació n de HE con cardiopatía congé nita cianó gena es infrecuente, y tras una revisió n de la base de datos MEDLINE desde 1990 hasta 2010 con las palabra clave hematopoyesis extramedular, cardiopatı´a conge´nita y masa presacra, hemos encontrado só lo tres casos 6,7 .…”

Section: Sr Editorunclassified

Hematopoyesis extramedular presacra secundaria a cardiopatía congénita cianógena

et al. 2012

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“…In the final phase of gestation, and up to the age of five years, erythrocytes are produced exclusively by the bone marrow 13 , although there are small areas of the liver that are capable of doing this 14 .…”

Section: Introductionmentioning

confidence: 99%

“…Extramedullary hematopoiesis occurs infrequently, as a compensatory mechanism for alterations of medullary hematopoiesis 13 .…”

Section: Introductionmentioning

confidence: 99%

Hepatic damage in newborns from female rats exposed to the pesticide derivative ethylenethiourea

et al. 2012

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PURPOSE:To evaluate hepatic morphological-histological abnormalities in newborns from female rats exposed to ethylenethiourea. METHODS:A randomized study was conducted on fifty-five newborn Wistar rats were studied: 34 in the experimental group, whose mothers had been exposed to 1% ethylenethiourea; and 21 in the control group, whose mothers had received 0.9% physiological solution. The solution was administered via gavage on the 11 th day of gestation. Cesarean section was performed on the 20 th day of gestation. The newborns' livers were examined and any morphological-histological abnormalities were registered. The presence of megakaryocytes was quantified in 50 microscope fields, as the total number of these cells per mm 2 . RESULTS:The entire experimental group presented abnormalities of embryonic formation, with musculoskeletal anomalies, digestive system anomalies, hepatic congestion and friability, hydrops and delayed intrauterine growth. The histopathological analysis showed that morphological-histological hepatic destructuring had occurred in all entire experimental with removal of the hepatic trabeculae and severe hepatic megakaryocytosis. The mean megakaryocyte density ranged from 107.9 to 114.2 per mm 2 , and it was eight times greater than in the control group, thus characterizing a situation of extramedullary hematopoiesis. CONCLUSION:The fetal exposure to ethylenethiourea caused hepatic damage characterized by severe extramedullary hematopoiesis.Key words: Pesticides. Ethylenethiourea. Liver. Hematopoiesis, Extramedullary. Pregnancy, Animal. Animals, Newborn. Rats. RESUMO OBJETIVO:Avaliar alterações hepáticas morfohistológicas em recém-nascidos de ratas prenhes expostas à etilenotioureia. MÉTODOS:Realizado ensaio randomizado em animais de experimentação, onde foram estudados 55 recém-nascidos de ratas Wistar, 34 do Grupo Experimento, expostas a etilenotioureia 1% e 21 do Grupo Controle, em que a rata prenhe recebeu solução fisiológica 0,9%, ambos por gavagem no 11º dia de gestação. Realizada no 20º dia de gestação cesariana, analisados os fígados dos recém-nascidos e registradas as alterações morfohistológicas. Realizou-se a quantificação dos megacariócitos em 50 campos microscópicos, avaliando a quantidade total destas células por mm². RESULTADOS:Todos os recém-nascidos do Grupo Experimento apresentaram alterações na formação embrionária, com anomalias musculoesqueléticas, anormalidades do sistema digestório, congestão e friabilidade hepática, hidropisia e crescimento intrauterino retardado. A análise histopatológica mostrou desestruturação hepática morfohistológica em todos os recém-nascidos expostos à etilenotioureia, com destrabeculação dos hepatócitos e intensa megacariocitose hepática, apresentando média da densidade deLemos PVRB et al. -Acta Cirúrgica Brasileira -Vol. 27 (12) 2012megacariócitos de 107,9 até 114,2 por mm 2 sendo cerca de oito vezes maior que no Grupo Controle, caracterizando hematopoese extramedular. CONCLUSÃO:A exposição fetal a etilenotioureia provocou danos hepát...

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Hematopoyesis extramedular: ¿mecanismo compensador o síndrome clínico? Descripción de un caso y revisión bibliográfica

Cited by 5 publications

References 33 publications

A common complication of myelofibrosis presenting as a rare finding in cerebrospinal fluid cytology

A common complication of myelofibrosis presenting as a rare finding in cerebrospinal fluid cytology

Hematopoyesis extramedular presacra secundaria a cardiopatía congénita cianógena

Hepatic damage in newborns from female rats exposed to the pesticide derivative ethylenethiourea

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