Hematoporphyrin phototherapy of cancer

Berns, Michael W.; Wile, Alan G.

doi:10.1016/s0167-8140(86)80034-2

Cited by 30 publications

(8 citation statements)

References 18 publications

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“…To increase the effectiveness of PRT he delivered red light (630 nm) from a dye laser through interstitial implantation of an optical fiber into solid tumors. However, reliability of the fiber optic delivery system is complicated by many other variables (type, design, and geometry) in addition to power, energy, and cost requirements [Berns, 1986].…”

Section: Hematoporphyrinmentioning

confidence: 99%

“…Bernsand Wile [1986] and Dougherty [ 1986] found that red light could penetrate only 1-2 cm of tissue with sufficient intensity to initiate photochemical reac tions necessary for an adequate therapeutic response. According to Svaasand [1984], precise dosimetry in PRT also requires detailed knowledge of drug con centration, photosensitization, and optical properties of the tissue under treatment.…”

Section: Hematoporphyrinmentioning

confidence: 99%

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Chemiluminescence and Hematoporphyrin Derivative: a Novel Therapy for Mammary Adenocarcinomas in Mice

Phillip

Maximuke²

1989

Oncology

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A Chemiluminescent System (CLS), using a Peroxyoxalate chemiluminescent solution (PCs), together with Hematoporphyrin derivative (HpD) Photofrin II., were utilized in the treatment of transplanted mammary adenocarcinomas in C₃H/HeJ female mice. Tumor bearing animals aged 2–4 months were divided into five groups; Group I was the control. Groups 2 and 4 compared the effectiveness of both reagents HpD and PCs which were administered by intratumor injections fractionated over a 96 hour period. Groups 3 and 5 compared the effectiveness of PCs alone. Tests of the PCs were conducted with and without the presence of luminescence. Fifty-three percent of the animals in Group 4 and 47% of the animals in Group 2 remained tumor free 120 days after the completion of treatment. Thirty percent of the animals in Groups 2 and 4 survived one year without tumor recurrence. The results of this study suggest that a chemical light system can be a viable alternative in Photodynamic Therapy (PDT) to laser light for the activation of HpD and treatment of cancer.

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Section: Hematoporphyrinmentioning

confidence: 99%

Section: Hematoporphyrinmentioning

confidence: 99%

Chemiluminescence and Hematoporphyrin Derivative: a Novel Therapy for Mammary Adenocarcinomas in Mice

Phillip

Maximuke²

1989

Oncology

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“…Among cancers that have been successfully treated are lung, bladder and esophageal tumors (Dougherty, 1986). Best results have been obtained with superficial lesions and although significant palliation of bulky tumors has been achieved (Balchum et a/., 1984;McCaughan eta/., 1984), cures may be difficult to obtain when the tumor size exceeds about 1.5 em (Berns and Wile, 1986;Prout eta/., 1987).…”

Section: Introductionmentioning

confidence: 99%

PHOTODYNAMIC THERAPY DOSIMETRY IN POSTMORTEM AND in vivo RAT TUMORS AND AN OPTICAL PHANTOM

Mr¹,

Tulip

Ms³

1990

Photochem & Photobiology

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Dosimetry in photodynamic therapy as currently practiced is empirical in that it does not account for optical properties of the target lesion. However, since light attenuation in tissue is unpredictable, measurements of optical properties are needed to ensure optimal light dose delivery. Further improvements in the uniformity of light dose distribution in tumors can be afforded by implanting multiple light sources. A technique is described in which the use of multiple cylindrical sources was combined with measurements of light energy fluence rate in the tumor. Six sources were placed within translucent plastic needles, which were inserted into tumors in a parallel array. Tumor attenuation characteristics were measured by placing a miniature light detector in one needle, while illuminating a cylindrical source in another, nearby, needle. This process was repeated for different needle pairs. In one postmortem and two in vivo tumors the absorption coefficient, transport scattering coefficient and penetration depth ranged from 0.56-0.81 cm-1, 9.4-15.2 cm-1 and 1.7-2.3 mm, respectively. Apparent penetration depths for in vivo tumors changed with time, during experiments. Predictions of dosimetry were generally consistent with direct measurements of light in tumors. Somewhat better agreement was observed in an optical phantom.

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“…The antitumour effect of systemically administered haematoporphyrin derivatives and the local application of light to tumours, has been intensively investigated in the last decade (for reviews see [1][2][3][4]. Photodynamic therapy (PDT) has now been used to treat effectively a variety of human tumours (1,5).…”

mentioning

confidence: 99%

Vascular Effects of Photodynamic therapy in an intraocular Retinoblastoma-Like Tumour

Horsman

Winther

1989

Acta Oncologica

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Hematoporphyrin phototherapy of cancer

Cited by 30 publications

References 18 publications

Chemiluminescence and Hematoporphyrin Derivative: a Novel Therapy for Mammary Adenocarcinomas in Mice

Chemiluminescence and Hematoporphyrin Derivative: a Novel Therapy for Mammary Adenocarcinomas in Mice

PHOTODYNAMIC THERAPY DOSIMETRY IN POSTMORTEM AND in vivo RAT TUMORS AND AN OPTICAL PHANTOM

Vascular Effects of Photodynamic therapy in an intraocular Retinoblastoma-Like Tumour

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