Hematoporphyrin‐Derivative and Photoradiation Therapy of Malignant Tumors

McCaughan, James S.; Guy, Jerry T.; Hawley, Philip C.; Hicks, William; Inglis, W. K.; Laufman, Leslie R.; May, Eugene; Nims, Thomas A.; Sherman, Rand

doi:10.1002/lsm.1900030302

Cited by 48 publications

(17 citation statements)

References 5 publications

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“…76 Since then, PDT has been employed in many thousands of patients for early and locally advanced stages of cancers. PDT is used in esophageal cancer for patients with locally advanced intraluminal tumors.…”

Section: 75mentioning

confidence: 99%

Untitled

2015

Surg J

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Section: 75mentioning

confidence: 99%

Untitled

2015

Surg J

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“…It was first adopted in treatment of esophageal malignancies since early 1980s and is now increasingly used in treatment of gastric cancer, biliary cancer and colon cancer. 1 The PDT accurately delivers light energy to the target lesion which enables selective tissue destruction and minimizes adjacent normal tissue damage. 2 Therefore it is possible to maintain gastrointestinal system's mechanical function and is suitable for repeated treatment of small lesions of immunocompromised patients.…”

Section: Introductionmentioning

confidence: 99%

The Effects of Photodynamic Therapy in Upper-Gastrointestinal Malignant Diseases

Kim

Park

2010

Gut Liver

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Photodynamic therapy (PDT) is a promising new modality that utilizes the combination of a photosensitizing chemical and visible light for the management of various solid malignancies, including gastrointestinal (GI) cancer. PDT has some advantages over chemotherapy in terms of its greater safety and lower toxicity in the treatment of malignant lesions. However, PDT has not been used widely for treating upper GI cancer due to its relatively low cost-effectiveness and anatomical characteristics of the GI system. Nevertheless, PDT may be an effective alternative therapy for early upper-GI cancer patients who are at a high risk of curative surgical resection or systemic chemotherapy. In some clinical studies, PDT for various upper GI cancer showed positiveresults. To improve the efficacy of PDT for upper GI cancer, development of photosensitezer and light delivery system is needed.

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“…Fast laser development and their prices decreasing discourage the use of lamps for PDT. A few works use non laser light sources for activating photodynamic process 10,11 remaining unknown, until now, some particularities concerning possible difference in the final effect when the excitation is laser or non laser light. This lack in experimental data encourages the development of non laser light sources for PDT studies.…”

Section: Introductionmentioning

confidence: 99%

Construction and evaluation of a non-laser optical system for photodynamic process excitation

Mesquita

Reis²,

Nicola

et al. 2004

Acta Cir. Bras.

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Purpose: To show that a non-laser light source can be constructed, using a 500 W Tungsten lamp and optical filters, and that this light source produces photodynamic effect via protoporphyrin IX (PpIX) similar to the effect produced by HeNe laser light. Methods: The broad band spectrum from a Tungsten lamp was filtered. Infrared and blue part of the spectrum was discarded by absorption process and the fraction of the spectrum, centered at the red portion, was filtered by an interference filter. Photodynamic effect was studied by the activity on endogenous PpIX of Harderian glands of Wistar rats. Twenty rats were used for the experiment. Each animal had its two Harderian gland surgically exposed, so one of them was treated with the system while the other was kept as control. After a 30 minutes period of treatment, the animals were sacrificed and their glands were removed for histological analysis. This analysis was compared to earlier published results obtained with HeNe laser light. Results: The resultant light source emission was centered around (636 ± 6.5) nm and gives up to 11.3 mW/cm2 power density. It produces photodynamic effect in Harderian gland, observed either by fluorescence spectroscopy or by histological microscopy. Conclusion: There is no noticeable difference in Photodynamic effect results if activated by HeNe laser or by the proposed non-laser light source emitting at the red portion of the spectrum. Key words: Photodynamic Therapy. Lasers. Harderian gland. RESUMOObjetivo: Descrever a construção de uma fonte de luz não-laser, a partir de uma lâmpada de Tungstênio e filtros óticos adequados e demonstrar que sua eficiência em estudos fotodinâmicos, mediados por protoporfirina IX, é semelhante a do laser de Hélio Neônio. Métodos: As regiões Infravermelha e Azul do espectro de emissão óptica de uma lâmpada de Tungstênio foram convenientemente descartadas por processos de absorção, enquanto que a fração centrada na região do vermelho foi removida com o uso de um filtro de interferência. O efeito fotodinâmico foi estudado, em glândula Harderiana de ratos Wistar em razão da produção endógena de protoporfirina IX (PpIX) por estas glândulas. Foram utilizados 20 ratos. Cada animal teve as duas glândulas expostas cirurgicamente, sendo uma delas tratada com a fonte não-laser e a outra mantida como controle. Após tratamento por 30 minutos os animais foram sacrificados e suas glândulas removidas para estudo histológico. Os resultados foram comparados a estudos realizados com laser de Hélio Neônio, já publicados. Resultados: A luz produzida pelo equipamento está centrada em torno de (636 ± 6,5) nm, fornecendo uma densidade de potência de 11,3 mW/cm2. Os efeitos fotodinâmicos produzidos na glândula Harderiana, podem ser observados tanto por espectroscopia de fluorescência como por microscopia ótica. Conclusão: Não foram observadas diferenças significativas nos resultados do efeito fotodinâmico obtidos com a fonte de luz não-laser proposta, em comparação aos resultados conhecidos com o uso do laser de Héli...

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Hematoporphyrin‐Derivative and Photoradiation Therapy of Malignant Tumors

Cited by 48 publications

References 5 publications

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The Effects of Photodynamic Therapy in Upper-Gastrointestinal Malignant Diseases

Construction and evaluation of a non-laser optical system for photodynamic process excitation

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