Hematopoietic Stem Cell Transplantation in Patients with Lymphomatoid Granulomatosis: A European Group for Blood and Marrow Transplantation Report

Abstract

Lymphomatoid granulomatosis (LG) is a very rare, Epstein-Barr virus-associated lymphoproliferative disorder of B cells. Prognosis is poor, particularly after relapse and no curative treatment exists. We report the results of high-dose therapy and autologous stem cell transplantation (ASCT) or reduced-intensity conditioning and allogeneic stem cell transplantation (alloSCT) in patients with multiply relapsed LG. A European Group for Blood and Marrow Transplantation survey identified 10 patients who had received 9 ASCT and 4 alloSCT. All patients had active disease at the time of transplantation. With a median follow-up of 5.1 (range, 1.4 to 6.3) years, 6 patients are alive and disease-free. Two ASCT patients died of septicemia early after transplantation, and 1 committed suicide after being in continuous complete remission 19 months after ASCT. Another patient allografted 4 years after ASCT remained disease-free but died of severe graft-versus-host disease 3 months after alloSCT. High-dose therapy followed by ASCT and alloSCT are effective therapeutic options and should be considered in all patients with refractory and multiply relapsed LG.

Primary diffuse large B-cell lymphoma or lymphomatoid granulomatosis grade 3: a atill-puzzling diagnosis in autopsy

“…Meanwhile, in view of the CD20 expression of tumor cells, rituximab has been used either as monotherapy37 or in association with chemotherapy 38. A European Group for Blood and Marrow Transplantation survey identified 6 patients in 10 as disease-free after bone marrow transplantation in a median follow-up of 5.1 years 39. Therefore, the differentiation between LYG and DLBL in our case would not be fundamental for treatment purposes.…”

A Case of Lymphomatoid Granulomatosis in a Lymph Node with Unique Clinical and Histopathologic Features

“…A total of 10 patients were studied, and results revealed that 6 patients remained alive and disease free, 2 had relapses, and 4 had died after transplantation. More studies need to be done to prove the efficacy of hematopoietic stem cell transplantation as a cure for LyG [ 16 ].…”

Suizidalität im klinischen Kontext hämatopoetischer Stammzelltransplantationen

“…ein einzelner Suizid erwähnt, dann aber nicht weiter ausgeführt [3,16]. In einem Fallbericht wurde der Suizid einer Patientin mit Rezidiv ihrer Grunderkrankung nach allogener HSCT beschrieben.…”

“…Doch davon befassensichlediglichsiebenArbeitentatsäch-lich mit dem Patientensuizid [3,15,16,[18][19][20]. Die übrigen Studien untersuchen Zusammenhänge auf immunologischer Ebene.…”