Hematopoietic Stem Cell Mobilization: Current Collection Approaches, Stem Cell Heterogeneity, and a Proposed New Method for Stem Cell Transplant Conditioning

Menendez-Gonzalez, Juan Bautista; Hoggatt, Jonathan

doi:10.1007/s12015-021-10272-1

Cited by 6 publications

(2 citation statements)

References 133 publications

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“…In the 1990's, G-CSF-mobilized HSPCs started to become the predominant graft source for autologous transplant, due to a faster hematologic recovery. Soon after, it also became the source of the majority of allogeneic HSC transplantation, associated with improved overall patient survival [69][70][71] . This change in the paradigm of clinical transplantation is due in part to the fact that mPB contains 5 to 10 times more CD34+ cells than BM aspirates and the number of HSPCs is critical for successful transplantation 72,73 .…”

Section: Discussionmentioning

confidence: 99%

Unravelling human hematopoietic progenitor cell diversity through association with intrinsic regulatory factors

Favaro,

Glass,

Borges

et al. 2023

Preprint

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Hematopoietic stem and progenitor cell (HSPC) transplantation is an essential therapy for hematological conditions, but finer definitions of human HSPC subsets with associated function could enable better tuning of grafts and more routine, lower-risk application. To deeply phenotype HSPCs, following a screen of 328 antigens, we quantified 41 surface proteins and functional regulators on millions of CD34+ and CD34- cells, spanning four primary human hematopoietic tissues: bone marrow, mobilized peripheral blood, cord blood, and fetal liver. We propose more granular definitions of HSPC subsets and provide new, detailed differentiation trajectories of erythroid and myeloid lineages. These aspects of our revised human hematopoietic model were validated with corresponding epigenetic analysis and in vitro clonal differentiation assays. Overall, we demonstrate the utility of using molecular regulators as surrogates for cellular identity and functional potential, providing a framework for description, prospective isolation, and cross-tissue comparison of HSPCs in humans.

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Section: Discussionmentioning

confidence: 99%

Unravelling human hematopoietic progenitor cell diversity through association with intrinsic regulatory factors

Favaro,

Glass,

Borges

et al. 2023

Preprint

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“…Hematopoietic stem cell transplantation (HSCT) is currently the oldest and only approved most effective stem cell therapy for the treatment of hematological disorders (8)(9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

Public awareness and understanding of stem cell treatments available in Saudi Arabia and their trust in hospitals and research centers involved in stem cell research—a cross sectional study

Aboalola,

Ramadan,

Baadhaim

et al. 2024

Front. Public Health

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IntroductionAlthough stem cell research and therapeutic applications hold great promise for medical advancements, and have rapidly progressed globally, there remains a lack of genuine public awareness of the status of this subject in Saudi Arabia. Successful integration of stem cell therapy into healthcare relies on public awareness, understanding, and trust. Therefore, we aimed in this cross-sectional study to assess the public’s knowledge, awareness, trust, support, participation, and confidence in stem cell treatments and centers involved in it.Materials and methodsA voluntary questionnaire of 20 questions was distributed randomly via social media outlets.ResultsThree thousand five hundred eighty four individuals participated in the survey, with approximately half of them falling within the age range of 35–50 years (46.71%). Majority of the participants, 90.71%, would like to know more about stem cell therapy and more than half of the participants (56.94%) were unfamiliar with the idea, and a comparable proportion (50.41%) expressed concerns about the safety of stem cell therapy. A lower level of awareness, indicated by a score of 5, was evenly distributed across all age groups and genders. However, regardless of gender, older participants—especially those 50 years of age or older—tended to report higher levels of confidence, trust, and support than participants in other age groups. Moreover, trust, support, participation, and confidence score for those attained high school or less was statistically significantly lower than those attained master’s or PhD degree. Of the participants, 33.57% had either received stem cell therapy themselves or known someone who had; about 24.07% of them reported that it was a cosmetic type of treatment.ConclusionThe study emphasizes the persistent need for awareness and educational initiatives to minimize the lack of public awareness and understanding of approved stem cell treatments in Saudi Arabia. It advocates for increased education, transparency, and communication to bridge knowledge gaps and enhance public trust to ensure the understanding of successful treatment.

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CRISPR/Cas-based gene editing in therapeutic strategies for beta-thalassemia

Zeng,

Lei,

et al. 2023

Hum. Genet.

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Hematopoietic Stem Cell Mobilization: Current Collection Approaches, Stem Cell Heterogeneity, and a Proposed New Method for Stem Cell Transplant Conditioning

Cited by 6 publications

References 133 publications

Unravelling human hematopoietic progenitor cell diversity through association with intrinsic regulatory factors

Unravelling human hematopoietic progenitor cell diversity through association with intrinsic regulatory factors

Public awareness and understanding of stem cell treatments available in Saudi Arabia and their trust in hospitals and research centers involved in stem cell research—a cross sectional study

CRISPR/Cas-based gene editing in therapeutic strategies for beta-thalassemia

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