Hematopoietic Stem and Progenitor Cells Exhibit Stage-Specific Translational Programs via mTOR- and CDK1-Dependent Mechanisms

Abstract

Highlights d HSPCs exhibit post-transcriptional and translational mechanisms of gene regulation d mTOR is targeted for proteasomal degradation in myeloid progenitors by c-Cbl d CDK1 regulates the activation of eIF4E-dependent translation in myeloid progenitors d Aberrant mTOR expression in myeloid progenitors results in increased myeloid cells

Mining database for the clinical significance and prognostic value of CBX family in skin cutaneous melanoma

“…Our study identified several kinase targets of CBX family in SKCM, including PLK1 and CDK1. Interestingly, we found that these kinases were associated with genomic stability, mitosis, and transcription activity 32,33 . Upregulation of PLK1 could maintain chromosomal instability and inhibit the genesis and proliferation of cancers 33,34 .…”

“…Interestingly, we found that these kinases were associated with genomic stability, mitosis, and transcription activity. 32,33 Upregulation of PLK1 could maintain chromosomal instability and inhibit the genesis and proliferation of cancers. 33,34 PLK1 alteration could facilitate cancerous transformation and promote cancer development.…”

“…32,33 Upregulation of PLK1 could maintain chromosomal instability and inhibit the genesis and proliferation of cancers. 33,34 PLK1 alteration could facilitate cancerous transformation and promote cancer development. 35 Therefore, CBX family may regulate SKCM development via PLK1.…”

Regulation of Ribosome Function by RNA Modifications in Hematopoietic Development and Leukemia: It Is Not Only a Matter of m6A

“…Furthermore, it was recently shown that differentiation of HSCs in myeloid progenitors requires not only a general increase in protein synthesis but also the translation of specific mRNAs [ 13 ]. Importantly, the alteration in ribosome levels that accompanies cell development can affect not only global protein synthesis but also the translation of specific transcripts.…”

“…However, within the epitranscriptome, modifications present in rRNAs and tRNAs largely prevail. Hematopoietic development requires tight control of protein synthesis [ 12 , 13 ]. Furthermore, translational deregulation strongly contributes to hematopoietic malignancies [ 14 , 15 ].…”