Hematopoietic Size Control: A Novel Role for Factor VIII Via the Thrombin/PAR1 Axis in Regulating the Interplay Between Dynamic Bone Structure and Long Term Survival and Mobilization of Hematopoietic Stem Cells
Abstract:19
Despite great progress in embryogenesis, the underlying mechanism that controls tissues and organs size remains a mystery. We previously showed that transplanted pig embryonic tissues are markedly enlarged in Factor VIII knockout (F8KO) mice, and identified a regulatory role for thrombin. Here, we describe a novel potential pathway through which coagulation factors might regulate size control of the hematopoietic system.
The hematopoietic stem cell (HSC) pool of F8KO mice exhib… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.