Hematopoietic SCT for adult T-cell leukemia/lymphoma: a review

Jabbour, Melhem; Tuncer, Hande H.; Castillo, Jorge J.; Butera, James N.; Roy, Tara S.; Pojani, J.; Malki, Monzr M. Al; Al-Homsi, Ahmad Samer

doi:10.1038/bmt.2011.27

Cited by 16 publications

(10 citation statements)

References 34 publications

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“…[9][10][11] Over the past decade, allogeneic hematopoietic cell transplantation (HCT) has been increasingly performed with the aim of improving dismal prognosis of patients who developed ATL. [12][13][14][15][16][17][18] Notably, some patients with ATL who relapsed after allogeneic HCT were shown to achieve remission only with the cessation of immunosuppressive agents, raising the question of whether the graft-versus-leukemia effect against ATL can be induced as part of graft-versus-host reaction. 19,20 In 1 study, among 10 patients who experienced relapse of ATL after transplantation and were withdrawn from immunosuppressive therapy, 8 developed graft-versus-host disease (GVHD), and 6 of them subsequently achieved The online version of the article contains a data supplement.…”

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confidence: 99%

Impact of graft-versus-host disease on outcomes after allogeneic hematopoietic cell transplantation for adult T-cell leukemia: a retrospective cohort study

Kanda

Hishizawa

Utsunomiya

et al. 2012

Blood

107

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Allogeneic hematopoietic cell transplantation (HCT) is an effective treatment for adult T-cell leukemia (ATL), raising the question about the role of graft-versus-leukemia effect against ATL. In this study, we retrospectively analyzed the effects of acute and chronic graft-versus-host disease (GVHD) on overall survival, disease-associated mortality, and treatment-related mortality among 294 ATL patients who received allogeneic HCT and survived at least 30 days posttransplant with sustained engraftment. Multivariate analyses treating the occurrence of GVHD as a time-varying covariate demonstrated that the development of grade 1-2 acute GVHD was significantly associated with higher overall survival (hazard ratio [HR] for death, 0.65; P = .018) compared with the absence of acute GVHD. Occurrence of either grade 1-2 or grade 3-4 acute GVHD was associated with lower disease-associated mortality compared with the absence of acute GVHD, whereas grade 3-4 acute GVHD was associated with a higher risk for treatment-related mortality (HR, 3.50; P < .001). The development of extensive chronic GVHD was associated with higher treatment-related mortality (HR, 2.75; P = .006) compared with the absence of chronic GVHD. Collectively, these results indicate that the development of mild-to-moderate acute GVHD confers a lower risk of disease progression and a beneficial influence on survival of allografted patients with ATL.

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confidence: 99%

Impact of graft-versus-host disease on outcomes after allogeneic hematopoietic cell transplantation for adult T-cell leukemia: a retrospective cohort study

Kanda

Hishizawa

Utsunomiya

et al. 2012

Blood

107

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“…The acute variant is the most aggressive, characterized by marked leukocytosis, skin lesions, massive lymphadenopathy, and organomegaly . Respiratory complications may appear because of tumor infiltration or opportunistic infections and sepsis, similar to case 1 (Fig.…”

Section: Discussionmentioning

confidence: 99%

“…Lymphomatous variant is also aggressive, with marked lymphadenopathy without leukemia . Chronic variant typically presents with an exfoliative skin rash, less prominent leukocytosis, and normocalcemia (Fig. ).…”

Section: Discussionmentioning

confidence: 99%

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Adult T‐cell leukemia/lymphoma in a Peruvian hospital in human T‐lymphotropic virus type 1 (HTLV‐1) positive patients

2017

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ATLL is developed after years of HTLV-1 carrier status; therefore, physicians should know the principal clinical and laboratory findings in order to make prompt diagnosis. Prognosis is still poor in aggressive and indolent variants, with survival rates from months to a few years. Treatment based on chemotherapy, antiretroviral, and allogeneic stem cell transplantation are improving survival rates but with limited results.

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“…The median survival time is approximately one year in patients treated with conventional chemotherapy (Tsukasaki et al 2007 ; Yamada et al 2001 ). Although target-based therapies using an anti-CCR4 antibody are now regarded as promising (Ishida et al 2012 ; Yamamoto et al 2010 ), allogeneic haematopoietic stem cell transplantation (HSCT) has been tested during this decade (Hishizawa et al 2010 ; Jabbour et al 2011 ; Okamura et al 2005 ; Utsunomiya et al 2001 ), and remission has been reported in some cases. These favourable results of HSCT are now discussed in connection with graft-versus-host reactions (Kanda et al 2012 ; Yonekura et al 2008 ).…”

Section: Introductionmentioning

confidence: 99%

A specific mode of microsatellite instability is a crucial biomarker in adult T-cell leukaemia/lymphoma patients

Miyashita

Fujii

Taguchi

et al. 2016

J Cancer Res Clin Oncol

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PurposeMicrosatellite instability (MSI) has been a long-standing biomarker candidate for drug resistance in tumour cells. Despite numerous clinical studies, the data in the literature are not conclusive. The complexity of the MSI phenomenon in some malignancies may, at least partly, account for the discrepancy. In addition, methodological problems are also pointed out in the assay techniques. We previously established a unique fluorescent technique in which the major methodological problems in conventional assays are overcome. Application of this technique has revealed two distinct modes of microsatellite alterations, i.e. Type A and Type B. More importantly, we demonstrated that Type A MSI is the direct consequence of defective DNA mismatch repair (MMR) that causes cellular resistance against antineoplastic agents.MethodWe first applied this technique to adult T-cell leukaemia/lymphoma (ATLL).ResultsThe MSI phenomenon was indeed observed in ATLLs (4/20, 20%). Intriguingly, the observed microsatellite alterations were invariably Type A, which implies that the tumours were MMR-defective. Indeed, clinical outcomes of patients with these MSI+ tumours were significantly worse. Furthermore, multivariate analysis revealed that Type A MSI is an independent prognostic factor.ConclusionThese observations strongly suggest the possibility of Type A MSI as a prognostic and potentially predictive biomarker in ATLL.

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Hematopoietic SCT for adult T-cell leukemia/lymphoma: a review

Cited by 16 publications

References 34 publications

Impact of graft-versus-host disease on outcomes after allogeneic hematopoietic cell transplantation for adult T-cell leukemia: a retrospective cohort study

Impact of graft-versus-host disease on outcomes after allogeneic hematopoietic cell transplantation for adult T-cell leukemia: a retrospective cohort study

Adult T‐cell leukemia/lymphoma in a Peruvian hospital in human T‐lymphotropic virus type 1 (HTLV‐1) positive patients

A specific mode of microsatellite instability is a crucial biomarker in adult T-cell leukaemia/lymphoma patients

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