Hematopoietic reconstitution dynamics of mobilized- and bone marrow-derived human hematopoietic stem cells after gene therapy

Scala, Serena; Ferrua, Francesca; Basso-Ricci, Luca; Dionisio, Francesca; Omrani, Maryam; Quaranta, Pamela; Hernández, Raisa Jofra; Core, Luca Del; Benedicenti, Fabrizio; Monti, Ilaria; Giannelli, Stefania; Fraschetta, Federico; Darin, Silvia; Albertazzi, Elena; Galimberti, Stefania; Montini, Eugenio; Calabria, Andrea; Cicalese, Maria Pia; Aiuti, Alessandro

doi:10.1038/s41467-023-38448-y

Suppressed Dissolution of Fluorine‐Rich SEI Enables Highly Reversible Zinc Metal Anode for Stable Aqueous Zinc‐Ion Batteries

Zhang,

Shen,

Xi

et al. 2024

Angewandte Chemie

3

0

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The instability of the solid electrolyte interface (SEI) is a critical challenge for the zinc metal anodes, leading to an erratic electrode/electrolyte interface and hydrogen evolution reaction (HER), ultimately resulting in anode failure. This study uncovers that the fluorine species dissolution is the root cause of SEI instability. To effectively suppress the F‐ dissolution, an introduction of low‐polarity molecule, 1,4‐thioxane (TX), is proposed, which reinforces the stability of the fluorine‐rich SEI. Moreover, the TX molecule has a strong affinity for coordinating with Zn2+ and adsorbing at the electrode/electrolyte interface, thereby diminishing the activity of local water and consequently impeding SEI dissolution. The robust fluorine‐rich SEI layer promotes the high durability of the zinc anode in repeated plating/stripping cycles, while concurrently suppressing HER and enhancing Coulombic efficiency. Furthermore, the Zn||KVOH full cell exhibits excellent capacity retention, averaging 6.8 mAh cm‐2 with 98% retention after 400 cycles, even at high loading with a lean electrolyte. This work offers a novel perspective on SEI dissolution as a key factor in anode failure, providing valuable insights for the electrolyte design in energy storage devices.

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Suppressed Dissolution of Fluorine‐Rich SEI Enables Highly Reversible Zinc Metal Anode for Stable Aqueous Zinc‐Ion Batteries

Zhang,

Shen,

Xi

et al. 2024

Angew Chem Int Ed

0

View full text Add to dashboard Cite

The instability of the solid electrolyte interface (SEI) is a critical challenge for the zinc metal anodes, leading to an erratic electrode/electrolyte interface and hydrogen evolution reaction (HER), ultimately resulting in anode failure. This study uncovers that the fluorine species dissolution is the root cause of SEI instability. To effectively suppress the F‐ dissolution, an introduction of low‐polarity molecule, 1,4‐thioxane (TX), is proposed, which reinforces the stability of the fluorine‐rich SEI. Moreover, the TX molecule has a strong affinity for coordinating with Zn2+ and adsorbing at the electrode/electrolyte interface, thereby diminishing the activity of local water and consequently impeding SEI dissolution. The robust fluorine‐rich SEI layer promotes the high durability of the zinc anode in repeated plating/stripping cycles, while concurrently suppressing HER and enhancing Coulombic efficiency. Furthermore, the Zn||KVOH full cell exhibits excellent capacity retention, averaging 6.8 mAh cm‐2 with 98% retention after 400 cycles, even at high loading with a lean electrolyte. This work offers a novel perspective on SEI dissolution as a key factor in anode failure, providing valuable insights for the electrolyte design in energy storage devices.

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Construction of Tumor Microenvironment‐Responsive Gene Carriers

Lin,

Yu,

Yang

et al. 2023

ChemNanoMat

0

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Peptide‐ and polypeptide‐based self‐assembling gene delivery systems have received considerable attention owing to their inherent biocompatibility and bioactivity. Gene carriers based on elastin‐like polypeptides (ELPs) have been extensively studied because of their controllability and unique temperature responsiveness. The (EK)10‐PLGLAG‐Tat polypeptide sequence was selected for tumor gene delivery, with ELP serving as the hydrophobic core. In this sequence, a hydration layer can be formed on the surface of the carrier using the zwitterionic peptide segment (EK)10, which helps prevent the nonspecific adsorption of plasma proteins. Additionally, the MMP‐2 enzyme‐responsive PLGLAG peptide segment is responsible for exposing the cell‐penetrating peptide Tat specifically near tumor cells, facilitating the penetration of tumor cells. To introduce (EK)10‐PLGLAG‐Tat into the self‐assembling carrier while ensuring its bioactivity, a leucine zipper ZR/ZE with opposite charges was used to link it to the ELP. Because of its high specificity and low systemic toxicity, the carrier was named environmentally responsive gene carrier (ERGV). Experimental results demonstrated that the ERGV effectively removed (EK)10 in MMP‐2 overexpressed environments, altering the surface charge from negative to positive and facilitating ssDNA delivery into tumor cells. These findings highlight the potential of ERGVs as a safe and efficient method for targeted gene delivery to tumors.

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Hematopoietic reconstitution dynamics of mobilized- and bone marrow-derived human hematopoietic stem cells after gene therapy

Cited by 8 publications

References 65 publications

Suppressed Dissolution of Fluorine‐Rich SEI Enables Highly Reversible Zinc Metal Anode for Stable Aqueous Zinc‐Ion Batteries

Suppressed Dissolution of Fluorine‐Rich SEI Enables Highly Reversible Zinc Metal Anode for Stable Aqueous Zinc‐Ion Batteries

Suppressed Dissolution of Fluorine‐Rich SEI Enables Highly Reversible Zinc Metal Anode for Stable Aqueous Zinc‐Ion Batteries

Construction of Tumor Microenvironment‐Responsive Gene Carriers

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