Hematopoietic Progenitors Derived from Human Embryonic Stem Cells

Kaufman, Dan S.

doi:10.1007/978-1-59259-423-8_12

Cited by 24 publications

(43 citation statements)

References 78 publications

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“…Skin and neurons have been formed, indicating ectodermal differentiation [9][10][11][12]. Blood, cardiac cells, cartilage, endothelial cells, and muscle have been formed, indicating mesodermal differentiation [13][14][15]. Pancreatic cells have also been formed, indicating endodermal differentiation [16].…”

Section: Stem Cells and Other Pluripotent Cell Typesmentioning

confidence: 99%

Regenerative medicine strategies

Atala

2012

Journal of Pediatric Surgery

131

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Section: Stem Cells and Other Pluripotent Cell Typesmentioning

confidence: 99%

Regenerative medicine strategies

Atala

2012

Journal of Pediatric Surgery

131

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“…To date, neural, pancreatic, and cardiac lineages have been the most claimed differentiation areas of hESCs as a result of intense interest in developing cell-based therapies for neurodegenerative diseases, paralysis, diabetes, and heart diseases Tables 3 - 5 . In addition, pluripotent hESCs have been claimed differentiation into many other clinically-relevant lineages and cell types in vitro through multi-lineage germ-layer induction, including hematopoieticcells [96, 97], hepatocytes [100-103], connective tissue progenitors [104], osteoblast and chondrocyte precursors [105-107], and mesenchymal stem cells [108, 109]. However, developing practical and efficient technology to be able to produce a large population of uniform uncontaminated progenies from hESCs for therapeutic application remains as a major challenge.…”

Section: Differentiation Of Hescsmentioning

confidence: 99%

Patents on Technologies of Human Tissue and Organ Regeneration from Pluripotent Human Embryonic Stem Cells

Parsons¹,

Teng²,

Moore³

et al. 2011

RPGM

135

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Human embryonic stem cells (hESCs) are genetically stable with unlimited expansion ability and unrestricted plasticity, proffering a pluripotent reservoir for in vitro derivation of a large supply of disease-targeted human somatic cells that are restricted to the lineage in need of repair. There is a large healthcare need to develop hESC-based therapeutic solutions to provide optimal regeneration and reconstruction treatment options for the damaged or lost tissue or organ that have been lacking. In spite of controversy surrounding the ownership of hESCs, the number of patent applications related to hESCs is growing rapidly. This review gives an overview of different patent applications on technologies of derivation, maintenance, differentiation, and manipulation of hESCs for therapies. Many of the published patent applications have been based on previously established methods in the animal systems and multi-lineage inclination of pluripotent cells through spontaneous germ-layer differentiation. Innovative human stem cell technologies that are safe and effective for human tissue and organ regeneration in the clinical setting remain to be developed. Our overall view on the current patent situation of hESC technologies suggests a trend towards hESC patent filings on novel therapeutic strategies of direct control and modulation of hESC pluripotent fate, particularly in a 3-dimensional context, when deriving clinically-relevant lineages for regenerative therapies.

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“…Kaufman and coworkers [19] have shown that cultivation of human ES cells on mouse bone marrow or yolk sac stromal cell lines can induce differentiation of a small proportion of the cells into hematopoietic progenitor cells. The hematopoietic precursors were positive for CD34 and expressed transcription factors characteristic of early blood cell precursors.…”

Section: "Human Es Cells Can Produce Several Cell Types Of Clinical Smentioning

confidence: 99%

Overview of the Current Status of Research on Human Pluripotent Stem Cells

Pera

2002

Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschu

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Seventeen years after the first description of the derivation and properties of mouse embryonic stem (ES) cells [1,2], reported the isolation of human ES cells from blastocysts.The derivation of human ES cells has led to hopes that their availability will revolutionise biomedical research and transplantation medicine.While it is not difficult to envision potential applications of human ES cells in research or regenerative medicine, many obstacles must be overcome before these cells are used, for example, in high throughput assays to elucidate gene function or to screen chemical libraries for active compounds, and before clinical trials in transplantation can begin. Although the challenges are complex, there has already been significant progress in our basic understanding of human pluripotent stem cell biology.I review that progress here. I consider aspects of the biology of human ES cells and compare them to the better characterised mouse ES cells, then discuss recent advances in the biology of human ES cells.This review will also touch on the more limited studies to date using embryonic germ (EG cells) [4] derived from human embryonic or foetal gonads.

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Hematopoietic Progenitors Derived from Human Embryonic Stem Cells

Cited by 24 publications

References 78 publications

Regenerative medicine strategies

Regenerative medicine strategies

Patents on Technologies of Human Tissue and Organ Regeneration from Pluripotent Human Embryonic Stem Cells

Overview of the Current Status of Research on Human Pluripotent Stem Cells

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